Technology Process of 1-(2,4-difluorophenyl)-1,1,2-trimethoxypropane
There total 4 articles about 1-(2,4-difluorophenyl)-1,1,2-trimethoxypropane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / AlCl3 / 4 h / 25 - 30 °C
2: 1.) potassium carbonate / 1) 1,2-dichloroethane, 0 deg C, 1 h; 2) 1,2-dichloroethane, 0 deg C, 5 h
3: 94.5 percent / HCl / diethyl ether / 0.67 h / 0 °C
4: 1.) sodium hydride / 1) N,N-dimethylformamide, 0 deg C, 10 min; 2) DMF, 0 deg C, 2 h
With
hydrogenchloride; aluminium trichloride; sodium hydride; potassium carbonate;
In
diethyl ether;
DOI:10.1246/bcsj.67.1427
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) potassium carbonate / 1) 1,2-dichloroethane, 0 deg C, 1 h; 2) 1,2-dichloroethane, 0 deg C, 5 h
2: 94.5 percent / HCl / diethyl ether / 0.67 h / 0 °C
3: 1.) sodium hydride / 1) N,N-dimethylformamide, 0 deg C, 10 min; 2) DMF, 0 deg C, 2 h
With
hydrogenchloride; sodium hydride; potassium carbonate;
In
diethyl ether;
DOI:10.1246/bcsj.67.1427
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 94.5 percent / HCl / diethyl ether / 0.67 h / 0 °C
2: 1.) sodium hydride / 1) N,N-dimethylformamide, 0 deg C, 10 min; 2) DMF, 0 deg C, 2 h
With
hydrogenchloride; sodium hydride;
In
diethyl ether;
DOI:10.1246/bcsj.67.1427
