1569644-99-0

Basic information

• Product Name: (E)-3-fluoro-N'-isopropyl-N'-(3-(1-propyl-1H-indol-3-yl)acryloyl)benzohydrazide
• Synonyms: (E)-3-fluoro-N'-isopropyl-N'-(3-(1-propyl-1H-indol-3-yl)acryloyl)benzohydrazide
• CAS NO: 1569644-99-0
• Molecular Weight: 407.488
• Mol File: 1569644-99-0.mol

Chemical Properties

• CAS DataBase Reference: (E)-3-fluoro-N'-isopropyl-N'-(3-(1-propyl-1H-indol-3-yl)acryloyl)benzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-fluoro-N'-isopropyl-N'-(3-(1-propyl-1H-indol-3-yl)acryloyl)benzohydrazide(1569644-99-0)
• EPA Substance Registry System: (E)-3-fluoro-N'-isopropyl-N'-(3-(1-propyl-1H-indol-3-yl)acryloyl)benzohydrazide(1569644-99-0)

Safety Data

• Hazardous Substances Data: 1569644-99-0(Hazardous Substances Data)

Upstream product

• 712-88-9 1-m-Fluorbenzoyl-2-isopropyliden-hydrazin 
• 19626-92-7 trans-3-(3-indolyl)acrylsaeuremethylester 
• 499-55-8 3-fluoro-benzoic acid hydrazide 
• 1204-06-4 trans-3-indole-acrylic acid 
• 2925-01-1 3-fluoro-N'-isopropylbenzohydrazide 
• 1569647-13-7 (E)-3-(1-propyl-1H-indol-3-yl)acrylic acid 

Relevant articles and documents

Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors

A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge.

Novel Indole Derivative or Pharmaceutically Acceptable Salt Thereof, Preparation Method Thereof, and Pharmaceutical Composition for Preventing or Treating Metabolic Diseases Containing Same as Active Ingredient

The present invention relates to an indole derivative, The indole derivative according to the present invention effectively inhibits the activity of diacylglycerol acyltransferase (DGAT) which induces metabolic diseases, such as obesity, diabetes, hyperlipidemia, or fatty liver and the like in lipid metabolism, thereby effectively regulating lipid metabolism and energy metabolism, and thus can be useful in pharmaceutical compositions for preventing or treating metabolic disease.