712-88-9

Upstream product

• 499-55-8 3-fluoro-benzoic acid hydrazide 
• 67-64-1 acetone 

Downstream Products

• 1569644-99-0 (E)-3-fluoro-N'-isopropyl-N'-(3-(1-propyl-1H-indol-3-yl)acryloyl)benzohydrazide 
• 1569644-93-4 (E)-N'-(3-(1-ethyl-1H-indol-3-yl)acryloyl)-3-fluoro-N'-isopropylbenzohydrazide 
• 1569644-81-0 (E)-3-fluoro-N'-(3-(1-isopentyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide 
• 1569644-47-8 (E)-3-fluoro-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide 
• 1407499-53-9 (E)-tert-butyl 3-(3-(2-(3-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 2925-01-1 3-fluoro-N'-isopropylbenzohydrazide 
• 1569644-71-8 (E)-tert-butyl 6-fluoro-3-(3-(2-(3-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1569644-65-0 (E)-tert-butyl 3-(3-(2-(3-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-6-methyl-1H-indole-1-carboxylate 
• 1569644-59-2 (E)-tert-butyl 3-(3-(2-(3-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-6-isopropyl-1H-indole-1-carboxylate 
• 1569644-53-6 (E)-tert-butyl 3-(3-(2-(3-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-5-methyl-1H-indole-1-carboxylate 

Relevant academic research and scientific papers

Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors

A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge.