156968-81-9 Usage
Uses
Used in Biochemical Research:
[1',2',3',4',5'-13C5]THYMIDINE is used as a labeled compound for studying the incorporation and metabolism of thymidine in biological systems. The presence of 13C isotopes allows for easier detection and tracking of the molecule during experiments, providing valuable insights into DNA synthesis and repair mechanisms.
Used in NMR Spectroscopy:
In the field of nuclear magnetic resonance (NMR) spectroscopy, [1',2',3',4',5'-13C5]THYMIDINE is used as a labeled reference compound for the analysis of DNA structures and interactions. The 13C-labeled thymidine enables researchers to differentiate between various nucleotide residues and monitor their behavior in different environments, contributing to a better understanding of DNA dynamics.
Used in Pharmaceutical Development:
[1',2',3',4',5'-13C5]THYMIDINE is also used in the development of new drugs targeting DNA-related processes. The labeled thymidine can be employed to study the binding and interaction of potential drug candidates with DNA, helping to identify and optimize compounds with desired pharmacological properties.
Used in Radiotracer Studies:
In the field of radiotracer studies, [1',2',3',4',5'-13C5]THYMIDINE can be used as a precursor for the synthesis of radiolabeled thymidine analogs. These radiotracers can be employed in the imaging of cellular proliferation and DNA synthesis, providing valuable information for the diagnosis and monitoring of various diseases, including cancer.
Used in Synthetic Chemistry:
[1',2',3',4',5'-13C5]THYMIDINE is used as a starting material or intermediate in the synthesis of various thymidine derivatives with potential applications in medicinal chemistry, drug development, and chemical biology. The presence of 13C isotopes can aid in the characterization and structural elucidation of these synthesized compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 156968-81-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,9,6 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 156968-81:
(8*1)+(7*5)+(6*6)+(5*9)+(4*6)+(3*8)+(2*8)+(1*1)=189
189 % 10 = 9
So 156968-81-9 is a valid CAS Registry Number.
156968-81-9Relevant articles and documents
NMR Spectroscopic Determination of the Solution Structure of a Branched Nucleic Acid from Residual Dipolar Couplings by Using Isotopically Labeled Nucleotides
Van Buuren, Bernd N. M.,Schleucher, Juergen,Wittmann, Valentin,Griesinger, Christian,Schwalbe, Harald,Wijmenga, Sybren S.
, p. 187 - 192 (2007/10/03)
Only a small set of magnetic-field-induced residual dipolar couplings is required to determine the global structure of branched nucleic acids. This is demonstrated for the example of the Holliday junction (shown schematically) after 13C labelin
Chemical Synthesis of 13C-labelled Monomers for the Solid-Phase and Template Controlled Enzymatic Synthesis of DNA and RNA Oligomers
Quant, S.,Wechselberger, R. W.,Wolter, M. A.,Woerner, K.-H.,Schell, P.,et al.
, p. 6649 - 6652 (2007/10/02)
The preparation of 13C-labelled ribonucleosides starting from -glucose 1 and the corresponding nucleobases 5a-e or 6a-e (N6-benzoyl-adenine, N2-acetyl-guanine, N4-benzoyl-cytosine, uracil and thymine) in 47-66percent overall yield is described.Their subsequent transformation into 5'-O-dimethoxytrityl protected DNA-phosphoramidites and 5'-O-dimethoxytrityl-2'-O-trialkylsilyl protected RNA-phosphor-amidites for the solid phase synthesis of DNA- and RNA-oligomers and to 5'-O-ribo- and deoxyribo-nucleosidetriphosphates for template controlled enzymatic synthesis (polymerase- or reverse transcriptase reaction) has been carried out.
