1569809-28-4Relevant academic research and scientific papers
One-Pot Cascade Reactions Leading to Pyrido[2′,1′:2,3]imidazo[4,5-c][1,2,3]triazolo[1,5-a]quinolines under Bimetallic Relay Catalysis with Air as the Oxidant
Wang, Ze,Li, Bin,Zhang, Xinying,Fan, Xuesen
, p. 6357 - 6363 (2016)
In this paper, we report an efficient one-pot synthesis of 1,2,3-triazole/quinoline-fused imidazo[1,2-a]pyridines starting from 2-(2-bromophenyl)imidazo[1,2-a]pyridines, alkynes, and sodium azide. This novel method involves a one-pot bimetallic relay-catalyzed cascade process combining azide-alkyne cycloaddition, C-N coupling between 1,2,3-triazole and aryl bromide, and intramolecular cross dehydrogenative C-C coupling between 1,2,3-triazole and imidazo[1,2-a]pyridine. Notable features of this protocol include simple starting materials, sustainable oxidants, reduced synthetic steps, and high efficiency.
Ligand-free, copper-catalyzed ullmann-type C-N coupling: Regioselective synthesis of azole-substituted imidazo[1,2-a]pyridines
Kaswan, Pinku,Pericherla, Kasiviswanadharaju,Kumar, Anil
supporting information, p. 2751 - 2757 (2014/01/06)
A simple and highly efficient protocol for the regioselective synthesis of azole-substituted imidazo[1,2-a]pyridines has been developed using a ligand-free, copper-catalyzed Ullmann-type C-N coupling of 2-(2-bromophenyl) imidazo[1,2-a]pyridines with different azoles and in situ generated 1,2,3-triazoles. The reactions proceeded smoothly to furnish azolo-imidazo[1,2-a]pyridines in good to excellent yields (65-96%). Georg Thieme Verlag Stuttgart New York.
