1570-09-8

Basic information

• Product Name: 5,7-Dihydroxy-3,4',8-trimethoxyflavone
• Synonyms: 5,7-Dihydroxy-3,4',8-trimethoxyflavone;5,7-Dihydroxy-3,8-diMethoxy-2-(4-Methoxyphenyl)-4H-chroMen-4-one
• CAS NO: 1570-09-8
• Molecular Formula: C₁₈H₁₆O₇
• Molecular Weight: 344
• Mol File: 1570-09-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 248-250 °C
• Boiling Point: 577.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.65±0.40(Predicted)
• CAS DataBase Reference: 5,7-Dihydroxy-3,4',8-trimethoxyflavone(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-Dihydroxy-3,4',8-trimethoxyflavone(1570-09-8)
• EPA Substance Registry System: 5,7-Dihydroxy-3,4',8-trimethoxyflavone(1570-09-8)

Safety Data

• Hazardous Substances Data: 1570-09-8(Hazardous Substances Data)

Usage

General Description

5,7-Dihydroxy-3,4',8-trimethoxyflavone, also known as hispidulin, is a flavone compound found in various plants such as Artemisia and Salvia species. It has been traditionally used in herbal medicine for its anti-inflammatory, anti-cancer, and neuroprotective properties. Studies have shown that 5,7-Dihydroxy-3,4',8-trimethoxyflavone has antioxidant and anti-inflammatory effects, making it a potential candidate for the treatment of inflammatory and neurodegenerative diseases. Additionally, it has shown promise in inhibiting the growth of cancer cells and inducing apoptosis, suggesting its potential as a therapeutic agent in cancer treatment. Overall, 5,7-Dihydroxy-3,4',8-trimethoxyflavone has garnered interest for its wide range of pharmacological activities and its potential as a natural remedy for various health conditions.

Upstream product

• 794-94-5 p-Methoxybenzoic anhydride 
• 42923-40-0 2,4-dihydroxy-3,6,ω-trimethoxyacetophenone 
• 85734-53-8 7-hydroxy-3,4',5,8-tetramethoxyflavone 
• 75-05-8 acetonitrile 
• 1570-10-1 7-benzyloxy-5-hydroxy-3,8-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 186581-53-3 diazomethane 
• 85571-15-9 Rhodionin 
• 110193-79-8 Acetic acid 3,5,8-trimethoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-7-yl ester 

Downstream Products

• 117155-41-6 3-hydroxy-4',8-dimethoxy-5,7-bis(tosyloxy)flavone 
• 3443-28-5 3,5,7-trihydroxy-8,4′-dimethoxyflavone 
• 117155-40-5 3,4',8-trimethoxy-5,7-bis(tosyloxy)flavone 
• 521-44-8 5-hydroxy-3,4',7,8-tetramethoxyflavone 
• 5128-45-0 5,7-diethoxy-3,8-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 5128-43-8 5,7-dihydroxy-3,4',8-trimethoxyflavone diacetate 

Relevant articles and documents

Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. 10. Selective Demethylation of 7-Hydroxy-3,5,8-trimethoxyflavones with Anhydrous Aluminum Halide in Acetonitrile or Ether

Demethylation of five 7-hydroxy-3,5,8-trimethoxyflavones and their acetates with anhydrous aluminum halides in acetonitrile or ether was studied and the following results were found. (1) The demethylation was apparently influenced by both solvents and afforded 5,7-dihydroxy-3,8-dimethoxyflavones in acetonitrile and 3,7-dihydroxy-5,8-dimethoxyflavones in ether as main products. (2) The demethylation with 5percent w/v anhydrous aluminum bromide in acetonitrile procedeed quantitatively to give a mixture of corresponding 5- and 3-hydroxyflavones, but that of 7-hydroxy-3,4',5,8-tetramethoxyflavone and its acetate with 10percent anhydrous aluminum chloride in acetonitrile afforded 6-acetyl-5,7-dihydroxy-3,4,8-trimethoxyflavone as a byproduct along with the 5- and 3-hydroxyflavones. (3) The demethylation of the acetates proceeded more smoothly than that of hydroxyflavones and was superior to that of the flavones with a hydroxy group. (4) These demethylations are available for the syntheses of 3- or 5-hydroxyflavones with no substituent at 6-position.