1570-09-8

Basic information

• Product Name: 5,7-Dihydroxy-3,4',8-trimethoxyflavone
• Synonyms: 5,7-Dihydroxy-3,4',8-trimethoxyflavone;5,7-Dihydroxy-3,8-diMethoxy-2-(4-Methoxyphenyl)-4H-chroMen-4-one
• CAS NO: 1570-09-8
• Molecular Formula: C₁₈H₁₆O₇
• Molecular Weight: 344
• Mol File: 1570-09-8.mol

Chemical Properties

• Melting Point: 248-250 °C
• Boiling Point: 577.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.65±0.40(Predicted)
• CAS DataBase Reference: 5,7-Dihydroxy-3,4',8-trimethoxyflavone(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-Dihydroxy-3,4',8-trimethoxyflavone(1570-09-8)
• EPA Substance Registry System: 5,7-Dihydroxy-3,4',8-trimethoxyflavone(1570-09-8)

Safety Data

• Hazardous Substances Data: 1570-09-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5,7-Dihydroxy-3,4',8-trimethoxyflavone is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
5,7-Dihydroxy-3,4',8-trimethoxyflavone is used as a neuroprotective agent for its potential to protect neurons from damage and degeneration, making it a candidate for the treatment of neurodegenerative diseases.
Used in Cancer Treatment:
5,7-Dihydroxy-3,4',8-trimethoxyflavone is used as an anticancer agent for its ability to inhibit the growth of cancer cells and induce apoptosis, suggesting its potential as a therapeutic agent in cancer treatment.
Used in Nutraceutical Industry:
5,7-Dihydroxy-3,4',8-trimethoxyflavone is used as a dietary supplement for its antioxidant properties, which can help protect the body from oxidative stress and support overall health.
Used in Cosmetic Industry:
5,7-Dihydroxy-3,4',8-trimethoxyflavone is used as an ingredient in skincare products for its anti-inflammatory and antioxidant properties, which can help reduce inflammation, protect the skin from environmental damage, and promote a healthy complexion.

Upstream product

• 1570-10-1 7-benzyloxy-5-hydroxy-3,8-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 186581-53-3 diazomethane 
• 85571-15-9 Rhodionin 
• 85734-53-8 7-hydroxy-3,4',5,8-tetramethoxyflavone 
• 75-05-8 acetonitrile 
• 110193-79-8 Acetic acid 3,5,8-trimethoxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromen-7-yl ester 
• 42923-40-0 2,4-dihydroxy-3,6,ω-trimethoxyacetophenone 
• 794-94-5 p-Methoxybenzoic anhydride 

Downstream Products

• 117155-40-5 3,4',8-trimethoxy-5,7-bis(tosyloxy)flavone 
• 3443-28-5 3,5,7-trihydroxy-8,4′-dimethoxyflavone 
• 117155-41-6 3-hydroxy-4',8-dimethoxy-5,7-bis(tosyloxy)flavone 
• 5128-45-0 5,7-diethoxy-3,8-dimethoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 5128-43-8 5,7-dihydroxy-3,4',8-trimethoxyflavone diacetate 
• 521-44-8 5-hydroxy-3,4',7,8-tetramethoxyflavone 

Relevant articles and documents

Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. 10. Selective Demethylation of 7-Hydroxy-3,5,8-trimethoxyflavones with Anhydrous Aluminum Halide in Acetonitrile or Ether

Demethylation of five 7-hydroxy-3,5,8-trimethoxyflavones and their acetates with anhydrous aluminum halides in acetonitrile or ether was studied and the following results were found. (1) The demethylation was apparently influenced by both solvents and afforded 5,7-dihydroxy-3,8-dimethoxyflavones in acetonitrile and 3,7-dihydroxy-5,8-dimethoxyflavones in ether as main products. (2) The demethylation with 5percent w/v anhydrous aluminum bromide in acetonitrile procedeed quantitatively to give a mixture of corresponding 5- and 3-hydroxyflavones, but that of 7-hydroxy-3,4',5,8-tetramethoxyflavone and its acetate with 10percent anhydrous aluminum chloride in acetonitrile afforded 6-acetyl-5,7-dihydroxy-3,4,8-trimethoxyflavone as a byproduct along with the 5- and 3-hydroxyflavones. (3) The demethylation of the acetates proceeded more smoothly than that of hydroxyflavones and was superior to that of the flavones with a hydroxy group. (4) These demethylations are available for the syntheses of 3- or 5-hydroxyflavones with no substituent at 6-position.

FLAVONOIDS OF THE EPIGEAL PART OF Rhodiola rosea. II. STRUCTURES OF NEW GLYCOSIDES OF HERBACETIN AND OF GOSSYPETIN

The structure of four new flavonol glycosides isolated from the epigeal part of Rhodiola rosea have been established: 7-O-α-L-rhamnopyranosylgossypetin (rhodiolgin), 8-O-β-D-glucopyranosyl-7-O-α-L-rhamnopyranosylgossypetin (rhodiolgidin), 8-O-β-D-glucopyranosyl-7-O-α-L-rhamnopyranosylherbacetin (rhodionidin), and 3-O-β-D-glucopyranosyl-8-O-β-D-xylopyranosylherbacetin (rhodalidin).The properties of the previously undescribed incomplete methyl ethers of herbacetin and gossypetin obtained during the structural analysis of the glycosides have been studied.It has been found that diazomenthane methylates the 5-OH groups in the diglycosides investigated.