1570052-89-9

Basic information

• Product Name: (E)-2-(3,4-difluoro-benzylidene)-hydrazine-carbothioamide
• Synonyms: (E)-2-(3,4-difluoro-benzylidene)-hydrazine-carbothioamide
• CAS NO: 1570052-89-9
• Molecular Weight: 215.226
• Mol File: 1570052-89-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-2-(3,4-difluoro-benzylidene)-hydrazine-carbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(3,4-difluoro-benzylidene)-hydrazine-carbothioamide(1570052-89-9)
• EPA Substance Registry System: (E)-2-(3,4-difluoro-benzylidene)-hydrazine-carbothioamide(1570052-89-9)

Safety Data

• Hazardous Substances Data: 1570052-89-9(Hazardous Substances Data)

Upstream product

• 34036-07-2 3,4 difluorobenzaldehyde 
• 79-19-6 thiosemicarbazide 

Relevant articles and documents

Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment

The eukaryotic initiation factor 4E (eIF4E)is an emerging anticancer drug target for specific anticancer therapy as a promising approach to overcome drug resistance and promote chemotherapy antitumor efficacy. A series of bromophenol-thiazolylhydrazone hybrids were designed, synthesized and evaluated for their antitumor activities. Among of them, the most potent compound 3e (EGPI-1)could inhibit the eIF4E/eIF4G interaction. Further mechanism study demonstrated EGPI-1 played an antitumor role in multiple modes of action including regulating the activity of eIF4E by inhibiting the phosphorylation of eIF4E and 4EBP1, disrupting mitochondrial function through the mTOR/4EBP1 signaling pathway, and inducing autophagy, apoptosis and ROS generation. Moreover, EGPI-1 showed good safety and favorable pharmacokinetic properties in vivo. These observations demonstrate that EGPI-1 may serve as an excellent lead compound for the development of new anticancer drugs that target the eIF4E/eIF4G interface and as a chemical genetic probe to investigate the role of the eIF4E in biological processes and human diseases.