157017-41-9

Usage

Uses

Used in Organic Synthesis:
1H-Pyrrole, 1-(2-iodophenyl)is used as a reagent and building block for the synthesis of complex organic molecules, leveraging its unique structure and properties to facilitate the formation of desired compounds.
Used in Pharmaceutical Research:
1H-Pyrrole, 1-(2-iodophenyl)is utilized in pharmaceutical research as a potential candidate for the development of new drugs, particularly due to its studied anti-cancer and anti-inflammatory properties, which make it a subject of interest for medicinal chemists seeking novel therapeutic agents.
Used in Medicinal Chemistry:
1H-Pyrrole, 1-(2-iodophenyl)is used as a starting material or intermediate in the design and synthesis of new pharmaceuticals, where its structural features can be exploited to create molecules with specific biological activities, such as those targeting cancer cells or modulating inflammatory responses.

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 615-43-0 2-iodophenylamine 
• 332-77-4 2,5-dihydro-2,5-dimethoxyfuran 
• 635-90-5 1-phenylpyrrole 
• 109-97-7 pyrrole 
• 615-42-9 1,2-Diiodobenzene 

Downstream Products

• 796843-38-4 3-(2-(1H-pyrrol-1-yl)phenyl)prop-2-yn-1-ol 
• 796843-21-5 1-[2-(prop-1-ynyl)phenyl]pyrrole 
• 1042073-86-8 7-(4-methylphenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-88-0 7-(4-nitrophenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-90-4 7-(2-nitrophenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-92-6 7-(2-chlorophenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-96-0 7-(2-methoxyphenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-98-2 N-(2-(5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinolin-7-yl)phenyl)acetamide 
• 1042074-00-9 ethyl 3-(5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinolin-7-yl)benzoate 
• 1042074-04-3 7-(3,4,5-trimethoxyphenyl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042074-08-7 7-(1-tosyl-1H-indol-3-yl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042074-10-1 7-(1-tosyl-1H-pyrazol-3-yl)-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 1042073-84-6 7-phenyl-5,6-dihydro-4H-benzo[de]pyrrolo[1,2-a]quinoline 
• 796843-22-6 1-(2-(phenylethynyl)phenyl)-1H-pyrrole 

Relevant academic research and scientific papers

Synthesis of fluoren-9-ones by the palladium-catalyzed cyclocarbonylation of o-halobiaryls

The synthesis of various substituted fluoren-9-ones has been accomplished by the palladium-catalyzed cyclocarbonylation of o-halobiaryls. The cyclocarbonylation of 4′-substituted 2-iodobiphenyls produces very high yields of 2-substituted fluoren-9-ones bearing either electron-donating or electron-withdrawing substituents. 3′-Substituted 2-iodobiphenyls afford 3-substituted fluoren-9-ones in excellent yields with good regioselectivity. This chemistry has been successfully extended to polycyclic fluorenones and fluorenones containing fused isoquinoline, indole, pyrrole, thiophene, benzothiophene, and benzofuran rings.

A solvent-free manganese(II) -catalyzed Clauson-Kaas protocol for the synthesis of N-aryl pyrroles under microwave irradiation

The first manganese-catalyzed modified Clauson-Kaas reaction for N-substituted pyrrole synthesis using 2,5-dimethoxytetrahydrofuran with variously substituted aromatic amines has been developed (up to 89% yield). This interesting neat strategy is free from additives including co-catalysts, ligands, and acids. Relatively low cost, environmentally benign, and handy Mn(NO3)2·4H2O is employed as the catalyst under microwave conditions with a very short reaction time (20?min). The above qualities attest to the green nature of this reaction.

Scalable electrochemical synthesis of diaryliodonium salts

Cyclic and acyclic diaryliodonium are synthesised by anodic oxidation of iodobiaryls and iodoarene/arene mixtures, respectively, in a simple undivided electrolysis cell in MeCN-HFIP-TfOH without any added electrolyte salts. This atom efficient process does not require chemical oxidants and generates no chemical waste. More than 30 cyclic and acyclic diaryliodonium salts with different substitution patterns were prepared in very good to excellent yields. The reaction was scaled-up to 10 mmol scale giving more than four grams of dibenzo[b,d]iodol-5-ium trifluoromethanesulfonate (>95%) in less than three hours. The solvent mixture of the large-scale experiment was recovered (>97%) and recycled several times without significant reduction in yield.

MICROCAPSULES AND PROCESSES FOR THEIR PREPARATION

The present invention provides microcapsules encapsulating hydrophilic or hydrophobic active agents in an inorganic shell, processes for their preparation and compositions comprising them.

Synthesis of indolizine derivatives containing eight-membered rings: Via a gold-catalyzed two-fold hydroarylation of diynes

A gold-catalyzed method for the construction of indolizines with eight-membered rings has been developed. The reaction proceeded through a two-fold hydroarylation with indole or pyrrole derivatives containing a 1,6-diyne using a tri(1-adamantyl)phosphine

Synthesis of 1,3-Azaphospholes with Pyrrolo[1,2- a]quinoline Skeleton and Their Optical Applications

A facile synthesis of 1,3-azaphospholes with a pyrrolo[1,2-a]quinoline skeleton has been described. These new annulated 1,3-azaphospholes exhibit good photoelectric performance and can be used as the emitting dopant in organic light-emitting diodes (OLEDs) and dye for bioimaging.

Palladium-Catalyzed Synthesis of Tetrasubstituted Olefins by Triple Domino Process

An efficient, highly regio- and stereoselective protocol for the synthesis of tetrasubstituted olefins was developed to take place by a palladium(0)-catalyzed triple domino process. It involves the formation of three new C?C bonds through double carbopalladation and C?H activation across 2-bromoaryl alkynyl biaryls/heteroaryls with norbornene. This method is practically simple with broad substrate scope and tolerates a wide range of substituents. The products bearing 9H-pyrrolo[1,2-a]indole motifs reveal intriguing solid state fluorescence properties and thus form a new class of aggregation induced emission (AIE) fluorophores. (Figure presented.).

Construction of benzo-fused indolizines, pyrrolo[1,2-a]quinolines via alkyne-carbonyl metathesis

The strategic use of a sequential Sonogashira coupling/intramolecular alkyne-carbonyl metathesis process for the synthesis of a pyridine ring from 1-(2-haloaryl)-1H-pyrrole-2-carbaldehydes allowed ready access to diverse novel benzo-fused indolizines, pyr

One-Pot Synthesis of Pyrrolo[1,2- a ]quinoxaline Derivatives via a Copper-Catalyzed Aerobic Oxidative Domino Reaction

A copper-catalyzed process for the synthesis of pyrrolo[1,2-a]quinoxalines from readily available α-amino acids and 1-(2-halophenyl)-1H-pyrroles is described. Different functional groups were well tolerated to give the corresponding products.

Expeditious synthesis of tetrasubstituted helical alkenes by a cascade of palladium-catalyzed C-H activations

Twisted molecules: A modular approach for the synthesis of tetrasubstituted helical alkenes by a palladium-catalyzed norbornene-mediated domino reaction is presented. This intermolecular domino process allows the formation of three C-C bonds in one operation through a C-H activation/carbopalladation/C-H activation sequence. Copyright