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Relevant academic research and scientific papers

Air-stable μ-oxo-bridged binuclear titanium(IV) salophen perfluorooctanesulfonate as a highly efficient and recyclable catalyst for the synthesis of bis(indolyl) methane derivatives

An air-stable μ-oxo-bridged binuclear Lewis acid of titanium(IV) salophen perfluorooctanesulfonate [{Ti(salophen)H2O}2O][OSO2C8F17]2 (1) was successfully synthesized by the reaction of TiIV(salophen)Cl2 with AgOSO2C8F17 and characterized by different techniques such as IR, NMR and HRMS. TG-DSC analysis showed that this complex was thermally stable at 220 °C. Meanwhile, it exhibited good solubility in polar organic solvents and good ionic dissociation in CH3CN solution. Fluorescence spectra and Hammett indicator results indicated that the complex had relatively strong acidity. And it showed high catalytic efficiency for the synthesis of bis(indolyl) methane derivatives through Friedel-crafts reaction of aldehyde/ketone with indoles. Moreover, it can be reused five times with minimal changes in catalytic efficiency.

Magnetically recyclable CuFe2O4 catalyst for efficient synthesis of bis(indolyl)methanes using indoles and alcohols under mild condition

Bis(3-indolyl)methanes (BIM) are highly valuable and appear in the core structure of many natural products and pharmacologically active compounds (anticancer, anti-inflammatory, antiobesity, antimetastatic, antimicrobial, etc.). Herein, we have disclosed

Facile access to bis(indolyl)methanes by copper-catalysed alkylation of indoles using alcohols under air

Bis(3-indolyl)methanes (BIM) are important and present in the structure of many alkaloid and bioactive compounds (anti-inflammatory, anticancer, antiobesity, antimicrobial, etc.). Herein, we have reported an air stable and convenient Cu(OAc)2 c

A novel three-phenyl bismuth organic (V) complex catalyst and its preparation method and a nitrogen-containing compound in the synthesis of the catalytic application

The invention provides a novel triphenyl organic bismuth (V) complex catalyst I, a preparation method thereof, and a synthesis method for nitrogen-containing compounds II-V under the catalysis of the novel triphenyl organic bismuth (V) complex catalyst I. The complex I is a cation-type organic bismuth complex, and the molecular formula is Ph3BiX2 (X=OSO2C4F9, OSO2C6F5, OSO2C8F17). The bismuth atom in the complex is connected with three triphenyls to show pentavalence. The other two perfluorooctane sulfonate roots and the cation part of the complex form an ionic bond. The synthesis method is used for synthesizing four types nitrogen-containing compounds, including bis(indolyl)methane II, dihydropyrimidinone III, dihydropyridine IV and beta-alkamine V, by taking the triphenyl organic bismuth compound as a catalyst and a conventional organic solvent as a reaction solvent. The method has the advantages of lower cost, high yield, simplicity and convenience in operation, zero pollution, repeated use of the catalyst and the like, and creates a cheap and environment-friendly way for preparing the nitrogen-containing compounds.

Air-stable Organobismuth(V) Bisperfluorooctanesulfonate as an Efficient Catalyst for the Synthesis of N-Containing Compounds

Triphenyl bismuth bisperfluorooctanesulfonate is an air- and water-stable Lewis acid. It exhibits high catalytic efficiency for the synthesis of nitrogen heterocycles such as diindolylmethane derivatives, dihydropyrimidinones, dihydropyridines and 1,2-disubstitued benzimidazoles under mild condition. Furthermore, it can be reused without loss of activity in a test of five cycles.This catalytic system affords a simple and efficient way for the synthesis of N-containing compounds.

A practical synthesis of bis(indolyl)methanes catalyzed by BF 3·Et2O

Practical BF3·Et2O catalyzed reactions between indoles and a series of carbonyl compounds at room temperature are described, which afford bis(indolyl)methanes with isolated yields up to 96%.