157064-65-8Relevant articles and documents
Biheterocycles: Synthesis and antimicrobial activity of 1',3',4'-oxadiazolyl/1'-pyrrolyl/1',2',4'-triazolylmethoxyindole derivatives
Gadaginamath, Guru S.,Kamat, Anand G.
, p. 544 - 551 (2007/10/03)
The chemoselectivity of C-5 ester over C-3 acetyl function towards the nucleophilic attack of hydrazine hydrate lead to the exclusive formation of substituted indol-5-yloxyacetic acid hydrazides (3a-h) from 5-ethoxycarbonylmethoxyindoles (2a-h).The acid hydrazides (3a-h) have been converted into the desired substituted 5-(5'-mercapto-1',3',4'-oxadiazol-2'-yl)methoxyindoles (5a-h), 5-(2',5'-dimethylpyrrol-1'-ylaminocarbonyl)methoxyindoles (6a-h) and 5-(4'-amino-5'-mercapto-1',2',4'-triazol-3'-yl)-methoxyindoles (7a-h).These acid hydrazides have also been converted intothe indol-5-ylomethylcarbothiosemicarbazides (8a-h) which on treatment with iodine-potassium iodide and sodium hydroxide give the desired 5-(5'-anilino-1',3',4'-oxadizol-2'-yl)-methoxyindoles and 5-(4'-phenyl-5'-mercapto-1',2',4'-triazol-3'-yl)-methoxyindoles respectively.Allthe newly synthesised compounds have been screened for their antibacterial and antifungal activities.