157096-32-7

Basic information

• Product Name: isopropyl (R)-2-cyano-2-methyl-6-phenylhexanoate
• CAS NO: 157096-32-7
• Molecular Weight: 273.375
• Mol File: 157096-32-7.mol

Chemical Properties

• CAS DataBase Reference: isopropyl (R)-2-cyano-2-methyl-6-phenylhexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: isopropyl (R)-2-cyano-2-methyl-6-phenylhexanoate(157096-32-7)
• EPA Substance Registry System: isopropyl (R)-2-cyano-2-methyl-6-phenylhexanoate(157096-32-7)

Safety Data

• Hazardous Substances Data: 157096-32-7(Hazardous Substances Data)

Upstream product

• 143619-32-3 (R)-isopropyl 2-cyano-2-methyl-5-oxopentanoate 
• 1100-88-5 benzyltriphenylphosphonium chloride 
• 30378-24-6 isopropyl 2-cyanopropanoate 

Downstream Products

• 157096-33-8 (R)-2-cyano-2-methyl-6-phenylhexamide 

Relevant articles and documents

Asymmetric Michael reaction of α-cyano carboxylates catalyzed by a rhodium complex with trans-chelating chiral diphosphine PhTRAP

Asymmetric Michael reaction of 2-cyanopropionates with vinyl ketones or acrolein in the presence of 0.1-1 mol% of a rhodium catalyst prepared in situ from RhH(CO)(PPh3)3 and a trans-chelating chiral diphosphine ligand (S,S)- (R,R)-PhTRAP in benzene at 3-5 °C gave optically active Michael adducts with high enantiomeric excesses (83-93% ee) in high yields. The reaction of 2- cyanopropionate with methacrolein and crotonaldehyde proceeded somewhat slowly, giving diastereomer mixtures in moderate enantioselectivities but in low diastereoselectivities. The reaction of 2-cyanobutyrate and 2-cyano-3- methylbutyrate with acrolein gave corresponding Michael adducts with much lower enantiomeric excesses than that of 2-cyanopropionates. The Michael addition product from acrolein was converted into an optically active α- methyl-α-amino acid.