1571144-30-3Relevant academic research and scientific papers
Synthesis of fluorene and/or benzophenone O-oxime ethers containing amino acid residues and study of their cardiovascular and antibacterial effects
Soltani Rad, Mohammad Navid,Behrouz, Somayeh,Zarenezhad, Elham,Moslemin, Mohammad Hossein,Zarenezhad, Ali,Mardkhoshnood, Mehdi,Behrouz, Marzieh,Rostami, Saeid
, p. 3810 - 3822 (2014)
The syntheses and biological studies of O -oxime ethers having α-amino acid residues as new analogs of IPS-339 have been described. In this synthesis, the reaction of fluorene and/or benzophenone O-oxime with epichlorohydrin or epibromohydrin afforded the corresponding O-oxime ether adducts. The N-alkylation of amino acid with O-oxime ether adducts led to synthesis of new analogs of IPS-339. The products were examined for their cardiovascular property. It was demonstrated that 2-(3-(9H-fluoren-9- ylideneaminooxy)-2-hydroxypropylamino)-3-methyl-butanoic acid as the most potent compound substantially reduces the heart rate of dogs. Compounds were also evaluated for their in vitro antibacterial activity against some Gram-negative and Gram-positive bacteria. The antibacterial screening proved the considerable antibacterial activity against both groups of bacteria. The docking analysis demonstrated the appropriate fitting of 2-(3-(9H-fluoren-9-ylideneaminooxy)-2- hydroxy-propylamino)-3-methyl-butanoic acid in human β2- adrenergic receptor active site. Potential drug toxicity for some active compounds has also been predicted. Springer Science+Business Media 2014.
