157116-68-2Relevant academic research and scientific papers
Oral delivery of sodium cromolyn: Preliminary studies in vivo and in vitro
Leone-Bay, Andrea,Leipold, Harry,Sarubbi, Donald,Variano, Bruce,Rivera, Theresa,Baughman, Robert A.
, p. 222 - 226 (1996)
Purpose. Herein we report the discovery of a group of derivatized α-amino acids that increase the oral bioavailability of sodium cromolyn. Methods. We prepared three N-acylated α-amino acids and used these compounds to demonstrate the oral delivery of cro
MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
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, (2018/11/22)
The present invention provides compounds, compositions thereof, and methods of using the same.
MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
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, (2017/05/15)
The present invention provides compounds, compositions thereof, and methods of using the same.
A simple chiral recognition system to investigate substituent effects on π-π Interactions
Snyder, Seth E.,Huang, Bin-Syuan,Chen, Yu-Tzu,Lin, Huei-Shian,Carey, James R.
supporting information; experimental part, p. 3442 - 3445 (2012/08/28)
We have used a simple molecular recognition system to study substituent effects in aromatic interactions. A series of substituted benzoylleucine diethyl amides with aromatic rings of varying electronic character were crystallized. All of the substituted d
Monoenomycin: A simplified trienomycin A analogue that manifests anticancer activity
Brandt, Gary E. L.,Blagg, Brian S. J.
supporting information; experimental part, p. 735 - 740 (2011/12/02)
Macrocyclic natural products are a powerful class of leadlike chemical entities. Despite commonly violating Lipinski's "rule of 5", these compounds often demonstrate superior druglike physicochemical and pharmacokinetic attributes when compared to their acyclic counterparts. However, the elaborate structural architectures of such molecules require rigorous synthetic investigation that complicates analogue development and their application to drug discovery programs. To circumvent these limitations, a conformation-based approach using limited structure-activity relationships and molecular modeling was implemented to design simplified analogues of trienomycin A, in which the corresponding analogues could be prepared in a succinct manner to rapidly identify essential structural components necessary for biological activity. Trienomycin A is a member of the ansamycin family of natural products that possesses potent anticancer activity. These studies revealed a novel trienomycin A analogue, monoenomycin, which manifests potent anticancer activity.
N-Acylated α-Amino Acids as Novel Oral Delivery Agents for Proteins
Leone-Bay, Andrea,Santiago, Noemi,Achan, Douglas,Chaudhary, Kiran,DeMorin, Frenel,et al.
, p. 4263 - 4269 (2007/10/03)
A series of N-acylated α-amino acids were synthesized and shown to improve the oral delivery of two protein drugs, salmon calcitonin (sCT) and interferon-α.Forty-five compounds in this series were tested in vivo in rats and primates.A significant positive
Composition containing a penem or carbapenem antibiotic and the use of the same
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, (2008/06/13)
Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially.
Composition containing a penem or carbapenem antibiotic
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, (2008/06/13)
Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. The composition may be prepared by simple mixing.
