157122-50-4Relevant academic research and scientific papers
First total synthesis of astechrome: Novel hydroxamic acid with an indole- pyrazine skeleton
Jing,Shimada,Maeda,Arai,Goto,Aoyagi,Ohta
, p. 277 - 279 (1994)
Astechrome (1), isolated from Aspergillus terreus IFO 6123 and 8835, was synthesized. Indolylmagnesium bromide (4) was coupled with a chloromethylpyrazine (5) to give 2-chloro-5-methoxy-3-methyl-6-[7-(3-methyl- 2-butenyl)indol-3-yl]methylpyrazine 1-oxide (6), which was converted to the Fe salt (9) of a hydroxamic acid derivative (8). Oxidation of 9 with (Co(salen) afforded 1.
