First total synthesis of astechrome: Novel hydroxamic acid with an indole- pyrazine skeleton

DOI: 10.1248/cpb.42.277

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 277 - 279 (1994)

Update date:2022-08-05

Topics:

Authors:

Jing Jing

Shimada Shimada

Maeda Maeda

Arai Arai

Goto Goto

Aoyagi Aoyagi

Ohta Ohta

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.277

Astechrome (1), isolated from Aspergillus terreus IFO 6123 and 8835, was synthesized. Indolylmagnesium bromide (4) was coupled with a chloromethylpyrazine (5) to give 2-chloro-5-methoxy-3-methyl-6-[7-(3-methyl- 2-butenyl)indol-3-yl]methylpyrazine 1-oxide (6), which was converted to the Fe salt (9) of a hydroxamic acid derivative (8). Oxidation of 9 with (Co(salen) afforded 1.

Full text of DOI:10.1248/cpb.42.277

NII-Electronic Library Service

Products guided by the article

Product name:2-hydroxy-5-methoxy-3-methyl-6-<7-(3-methyl-2-butenyl)indolin-3-yl>methylpyrazine 1-oxide

Cas No:157122-50-4

R&D Labs maybe for 157122-50-4

Tianjin Dongchang Fine Chemical Industry Co., Ltd.

Contact:+86-22-29894595

Address:Economic Developing Zone, Ji County, Tianjin, China
Jinan Great Chemical Co.,Ltd.

Contact:+86-531-58668191 58668193 58668196 58661173

Address:No 55,Beixiaoxinzhuang West Street,Jinan City, Shandong Province
Feis International Trade Co,. Ltd

Contact:13961823444-18235944442

Address:Wuxi jiangsu
Luoyang Aoda chemical Co.,Ltd.

Contact:+86-379-67518785 67516588

Address:MiaoWan industry district,YanShi City,Henan,China
ZHUHAI HAIRUIDE BIOSCIENCE AND TECHNOLOGY CO.,LTD

website:http://www.zhhairuide.com

Contact:+8613326687259/+86-756-7789199

Address:No.10 Yonghui Road

Relevant to this article

Synthesis of 2-(N-benzoylimino)-N-(9,10-dioxo-9,10-dihydroanthracen-1-yl) thiazoles

Doi:10.1007/s10593-014-1437-z
()
Synthesis and Reactivity of Some Thiochroman-3,4-diones.

Doi:10.1016/S0040-4020(01)85270-4
(1994)
Pd-catalyzed branching cyclizations of enediyne-imides toward furo[2,3-b ]pyridines

Doi:10.1021/ol500574b
(2014)
Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma

Doi:10.1021/acs.jmedchem.6b00777
(2016)
Synthesis and characterization of cobalt complexes with pentafluorophenylhydrazine: Nucleophilic attack of phenolic oxygen to pentafluorophenyl ring during condensation of two Schiff base ligands

Doi:10.1016/j.jfluchem.2014.01.013
(2014)
Structure-activity relationships among antifungal nylon-3 polymers: Identification of materials active against drug-resistant strains of Candida albicans

Doi:10.1021/ja500036r
(2014)

Article Doi