157126-72-2

Basic information

• Product Name: 1-(3-iodopropyl)-3-phenoxybenzene
• Synonyms: 1-(3-iodopropyl)-3-phenoxybenzene;1-(3-iodopropyl)-3-phenoxybenzene(WXC06284)
• CAS NO: 157126-72-2
• Molecular Formula: C₁₅H₁₅IO
• Molecular Weight: 338.18347
• Mol File: 157126-72-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3-iodopropyl)-3-phenoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-iodopropyl)-3-phenoxybenzene(157126-72-2)
• EPA Substance Registry System: 1-(3-iodopropyl)-3-phenoxybenzene(157126-72-2)

Safety Data

• Hazardous Substances Data: 157126-72-2(Hazardous Substances Data)

Usage

General Description

1-(3-iodopropyl)-3-phenoxybenzene is a chemical compound with the molecular formula C15H15IO. It is an organoiodine compound with a phenoxy group and a propyl chain attached to a benzene ring. 1-(3-iodopropyl)-3-phenoxybenzene is commonly used as a reagent in organic synthesis, specifically in the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. It is also a precursor to several other valuable compounds due to its useful chemical properties and reactivity. Additionally, it has been studied for its potential medicinal properties, particularly in the treatment of certain diseases and disorders.

Upstream product

• 77124-20-0 (E)-3-(3-phenoxyphenyl)acrylic acid 
• 39515-51-0 3-Phenoxybenzaldehyde 
• 1353578-78-5 C₁₆H₁₈O₄S 
• 106797-69-7 3-(3-phenoxyphenyl)propan-1-ol 
• 288-32-4 1H-imidazole 
• 683-08-9 Diethyl methylphosphonate 

Downstream Products

• 157126-73-3 3-Phenoxy-α-(diethoxyphosphinyl)benzenebutanesulfonic acid, cyclohexyl ester 
• 1026696-12-7 C₂₀H₂₇O₇PS 
• 1160847-81-3 C₃₃H₃₅O₆P 
• 1206886-39-6 C₂₃H₃₄O₆P₂ 
• 1160847-79-9 C₂₂H₂₃NO₂ 
• 1057672-66-8 C₁₆H₁₅NO 

Relevant articles and documents

Synthesis of key intermediate of phosphonosulfonates (BPH-652), 1-(3-iodopropyl)-3-phenoxy benzene

A convenient and efficient four-step synthesis of 1-(3-iodopropyl)-3-phenoxy benzene can be achieved by 3-phenoxybenzaldehyde and malonic acid in the presence of piperidine and pyridine to yield (E)-3-(3-phenoxyphenyl)-2-propenoic acid, esterification with methanol in the present of p -toluene sulfonic acid, reduction with sodium borohydride to give 3-(3-phenoxyphenyl)propan-1-ol and iodination of 3-(3-phenoxy phenyl) propan-1-ol using iodine and triphenylphosphine in the present of potassium iodide and imidazole and to afford the title compound in an overall yield of 55.6 %.

Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in staphylococcus aureus

Staphylococcus aureus produces a golden carotenoid virulence factor called staphyloxanthin (STX), and we report here the inhibition of the enzyme, dehydrosqualene synthase (CrtM), responsible for the first committed step in STX biosynthesis. The most acti

Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia

α-Phosphonosulfonate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula STR1 wherein R2 is OR5 or R5a ; R3 and R5 are independently H, alkyl, arylalkyl, aryl or cycloalkyl; R5a is H, alkyl, arylalkyl or aryl; R4 is H, alkyl, aryl, arylalkyl, or cycloalkyl;, Z is H, halogen, lower alkyl or lower alkenyl; and R1 is a lipophilic group which contains at least 7 carbons and is alkyl, alkenyl, alkynyl, mixed alkenyl-alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloheteroalkylalkyl; as further defined above; including pharmaceutically acceptable salts and or prodrug esters of the phosphonic (phosphinic) and/or sulfonic acids.