106797-69-7

Basic information

• Product Name: 3-(3-PHENOXY-PHENYL)-PROPAN-1-OL
• Synonyms: 3-(3-PHENOXY-PHENYL)-PROPAN-1-OL;3-Phenoxy-benzenepropanol;Benzenepropanol,3-phenoxy-;3-(3-phenoxyphenyl)propan-1-ol(WXC06283)
• CAS NO: 106797-69-7
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.28634
• Mol File: 106797-69-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 367.152°C at 760 mmHg
• Flash Point: 161.733°C
• Appearance: /
• Density: 1.104g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.576
• PKA: 15.04±0.10(Predicted)
• CAS DataBase Reference: 3-(3-PHENOXY-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-PHENOXY-PHENYL)-PROPAN-1-OL(106797-69-7)
• EPA Substance Registry System: 3-(3-PHENOXY-PHENYL)-PROPAN-1-OL(106797-69-7)

Safety Data

• Hazardous Substances Data: 106797-69-7(Hazardous Substances Data)

Usage

General Description

3-(3-phenoxy-phenyl)-propan-1-ol is a chemical compound that belongs to the class of alcohols. It is used in the production of various materials such as plastics, adhesives, and paints. It has a strong aroma and is often used as a fragrance in cosmetics and personal care products. 3-(3-PHENOXY-PHENYL)-PROPAN-1-OL has also been studied for its potential use in pharmaceuticals, particularly for its anti-inflammatory and antioxidant properties. However, it is important to handle this compound with care, as it can be hazardous if not used properly.

InChI:InChI=1/C15H16O2/c16-11-5-7-13-6-4-10-15(12-13)17-14-8-2-1-3-9-14/h1-4,6,8-10,12,16H,5,7,11H2

Upstream product

• 52888-69-4 ethyl 3-(3-phenoxyphenyl)propanoate 
• 61389-68-2 methyl 3-(3-hydroxyphenyl)propionate 
• 66417-46-7 trans-3-(3-hydroxyphenyl)acrylic acid methyl ester 
• 14755-02-3 3-hydroxy-trans-cinnamic acid 
• 87087-33-0 methyl 3-<(4-phenoxy)phenyl>propenoate 
• 77124-20-0 (E)-3-(3-phenoxyphenyl)acrylic acid 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 39515-51-0 3-Phenoxybenzaldehyde 
• 96283-94-2 (E)-ethyl 3-(3-phenoxyphenyl)-2-propenoate 
• 115488-27-2 methyl 3-(3-phenoxyphenyl)propanoate 
• 60-29-7 diethyl ether 
• 87087-33-0 methyl 3-(3-phenoxyphenyl)acrylate 

Downstream Products

• 105128-00-5 1-bromo-3-(3-phenoxyphenyl)propane 
• 1353578-78-5 C₁₆H₁₈O₄S 
• 157126-73-3 3-Phenoxy-α-(diethoxyphosphinyl)benzenebutanesulfonic acid, cyclohexyl ester 
• 1026696-12-7 C₂₀H₂₇O₇PS 
• 1206886-39-6 C₂₃H₃₄O₆P₂ 
• 1160847-81-3 C₃₃H₃₅O₆P 
• 1057672-66-8 C₁₆H₁₅NO 
• 122801-83-6 3-(3-phenoxyphenyl)propanal 
• 157126-72-2 1-(3-iodopropyl)-3-phenoxybenzene 

Relevant articles and documents

Synthesis of key intermediate of phosphonosulfonates (BPH-652), 1-(3-iodopropyl)-3-phenoxy benzene

A convenient and efficient four-step synthesis of 1-(3-iodopropyl)-3-phenoxy benzene can be achieved by 3-phenoxybenzaldehyde and malonic acid in the presence of piperidine and pyridine to yield (E)-3-(3-phenoxyphenyl)-2-propenoic acid, esterification with methanol in the present of p -toluene sulfonic acid, reduction with sodium borohydride to give 3-(3-phenoxyphenyl)propan-1-ol and iodination of 3-(3-phenoxy phenyl) propan-1-ol using iodine and triphenylphosphine in the present of potassium iodide and imidazole and to afford the title compound in an overall yield of 55.6 %.

Preparation method of 3-aryl propanol

The invention discloses a preparation method of 3-aryl propanol. According to the preparation method, 3-aryl benzaldehyde and acetate are dissolved into an organic solvent, a catalyst is added at a certain temperature to carry out condensation reactions to prepare 3-aryl-2-alkene ester, then 3-aryl-2-alkene ester and a reducing agent carry out reduction reactions to obtain the final product 3-aryl propanol. The provided method adopts aryloxy to replace benzaldehyde to carry out condensation reactions with acetate, and then the reaction product is reduced to prepare 3-aryl propanol. Aromatic aldehyde and acetate carry out condensation reactions in the presence of a catalyst to prepare a Knoevenagel like condensate namely 3-aryl-2-alkene ester, and then 3-aryl-2-alkene ester is reduced by a reducing agent to prepare aryl propanol. The total yield is greater than 80%. The content is more than 95%. The raw materials are cheap, and the sources are wide. The preparation method is safer and more convenient. Moreover, the production cost is low, the raw materials is nontoxic or little toxic, the total yield is high, the generated waste gas, waste water, and waste solid are little, and the industrialization is easy.

ANTI-BACTERIAL COMPOSITIONS AND METHODS INCLUDING TARGETING VIRULENCE FACTORS OF STAPHYLOCOCCUS AUREUS

This disclosure relates to compositions and methods including for the inhibition, prevention, and/or treatment of microbial infections, including infections from such pathogens as Staphylococcus aureus.