157126-75-5

Basic information

• Product Name: 4-iodobenzenepropanoic acid,ethyl ester
• Synonyms: 4-iodobenzenepropanoic acid,ethyl ester
• CAS NO: 157126-75-5
• Molecular Weight: 304.128
• Mol File: 157126-75-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-iodobenzenepropanoic acid,ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodobenzenepropanoic acid,ethyl ester(157126-75-5)
• EPA Substance Registry System: 4-iodobenzenepropanoic acid,ethyl ester(157126-75-5)

Safety Data

• Hazardous Substances Data: 157126-75-5(Hazardous Substances Data)

Upstream product

• 34633-08-4 ethyl 3-(4-iodophenyl)acrylate 
• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 501-52-0 3-Phenylpropionic acid 
• 1643-29-4 3-(4-iodophenyl)propionic acid 

Downstream Products

• 60075-78-7 3-(p-iodophenyl)-propanol 
• 172483-74-8 1-bromo-3-(4'-iodophenyl)propane 
• 1597430-42-6 3-(4-iodophenyl)propyloxyamine hydrochloride 
• 1597430-58-4 C₁₈H₂₂IN₃O₆ 
• 737825-20-6 ethyl 4-(4-iodophenyl)-2-oxobutanoate 
• 737825-25-1 N-{5-(4-iodobenzyl)-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide 
• 1443744-28-2 C₁₃H₁₃IN₂O₂S 
• 737825-19-3 methyl 4-({2-(acetylamino)-4-[2-(4-{[amino(imino)methyl]amino}phenyl)ethyl]-1,3-thiazol-5-yl}methyl)benzoate hydrochloride 
• 737825-29-5 methyl 4-[(2-(acetylamino)-4-{2-[4-({(Z)-[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}-amino)phenyl]ethyl}-1,3-thiazol-5-yl)methyl]benzoate 
• 737825-28-4 methyl 4-({2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-1,3-thiazol-5-yl}methyl)benzoate 
• 737825-27-3 N-{5-(4-(methoxycarbonyl)benzyl)-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide 
• 737825-24-0 N-[4-formyl-5-(4-iodobenzyl)-1,3-thiazol-2-yl]acetamide 
• 737825-23-9 ethyl 2-(acetylamino)-5-(4-iodobenzyl)-1,3-thiazole-4-carboxylate 
• 737825-22-8 ethyl 2-amino-5-(4-iodobenzyl)-1,3-thiazole-4-carboxylate hydrobromide 

Relevant articles and documents

Synthetic method of triazole compound

The invention discloses a synthetic method of a triazole compound N-((5-(4-iodophenyl)-2H-1,2,4-triazol-3-yl)methyl)-N-propylpropan-1-amine. The preparation method comprises the steps of carrying out reduction, acylation, imidization, ring closure, Boc removal and alkylation reaction on a starting raw material: 3-(4-iodophenyl)ethyl acrylate, so as to obtain a target product 7. The triazole compound is used as a template micromolecule for synthesizing various compound libraries.

Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia

α-Phosphonosulfonate compounds are provided which inhibit the enzyme squalene synthetase and thereby inhibit cholesterol biosynthesis. These compounds have the formula STR1 wherein R2 is OR5 or R5a ; R3 and R5 are independently H, alkyl, arylalkyl, aryl or cycloalkyl; R5a is H, alkyl, arylalkyl or aryl; R4 is H, alkyl, aryl, arylalkyl, or cycloalkyl;, Z is H, halogen, lower alkyl or lower alkenyl; and R1 is a lipophilic group which contains at least 7 carbons and is alkyl, alkenyl, alkynyl, mixed alkenyl-alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloheteroalkylalkyl; as further defined above; including pharmaceutically acceptable salts and or prodrug esters of the phosphonic (phosphinic) and/or sulfonic acids.