60075-78-7

Usage

InChI:InChI=1/C9H11IO/c10-9-5-3-8(4-6-9)2-1-7-11/h3-6,11H,1-2,7H2

Upstream product

• 122-97-4 3-Phenyl-1-propanol 
• 33994-44-4 3-(4-iodophenyl)propionic acid methyl ester 
• 122-72-5 3-phenylpropyl acetate 
• 157126-75-5 4-iodobenzenepropanoic acid,ethyl ester 
• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 1643-29-4 3-(4-iodophenyl)propionic acid 

Downstream Products

• 60075-80-1 Carbonic acid hexyl ester 3-(4-iodo-phenyl)-propyl ester 
• 60075-79-8 Carbonic acid ethyl ester 3-(4-iodo-phenyl)-propyl ester 
• 213264-51-8 3-(4-iodophenyl)propionaldehyde 
• 1052138-66-5 3-(4-iodophenyl)propyl methanesulfonate 
• 172483-74-8 1-bromo-3-(4'-iodophenyl)propane 
• 107399-42-8 3,3'-(1,4-phenylene)dipropanal 
• 63405-68-5 (2E,2'E)-3,3'-(1,4-phenylene)diacrylaldehyde 
• 85356-69-0 1-Iodo-4-(3-iodo-propyl)-benzene 
• 1052119-74-0 C₅₄H₈₈N₄O₁₃ 
• 1052138-68-7 3-[4-(3-azidopropyl)phenyl]pyridine 
• 1000547-83-0 3-(4-pyridin-3-ylphenyl)propylamine 
• 1052138-67-6 1-(3-azidopropyl)-4-iodobenzene 

Relevant academic research and scientific papers

One-pot regioselective synthesis of chromanyl(phenyl)-λ3- iodanes: Tandem oxidative cyclization and λ3-iodanation of 3-phenylpropanols

Reaction of 3-phenylpropanol with an activated iodosylbenzene - 18-crown-6 complex [Phl(OH)BF4-18C6] in dichloromethane in the presence of BF3-Et2O afforded directly the 6-chromanyl(phenyl)- λ3-iodane-18C6 compl

Stapled Peptides by Late-Stage C(sp3)?H Activation

Despite the importance of stapled peptides for drug discovery, only few practical processes to prepare cross-linked peptides have been described; thus the structural diversity of available staple motifs is currently limited. At the same time, C?H activati

4-alkyloxyimino derivatives of uridine-5′-triphosphate: Distal modification of potent agonists as a strategy for molecular probes of P2Y 2, P2Y4, and P2Y6 receptors

Extended N4-(3-arylpropyl)oxy derivatives of uridine-5′-triphosphate were synthesized and potently stimulated phospholipase C stimulation in astrocytoma cells expressing G protein-coupled human (h) P2Y receptors (P2YRs) activated by UTP (P2Y2/4R) or UDP (P2Y6R). The potent P2Y4R-selective N4-(3- phenylpropyl)oxy agonist was phenyl ring-substituted or replaced with terminal heterocyclic or naphthyl rings with retention of P2YR potency. This broad tolerance for steric bulk in a distal region was not observed for dinucleoside tetraphosphate agonists with both nucleobases substituted. The potent N 4-(3-(4-methoxyphenyl)-propyl)oxy analogue 19 (EC50: P2Y2R, 47 nM; P2Y4R, 23 nM) was functionalized for chain extension using click tethering of fluorophores as prosthetic groups. The BODIPY 630/650 conjugate 28 (MRS4162) exhibited EC50 values of 70, 66, and 23 nM at the hP2Y2/4/6Rs, respectively, and specifically labeled cells expressing the P2Y6R. Thus, an extended N4-(3- arylpropyl)oxy group accessed a structurally permissive region on three G q-coupled P2YRs, and potency and selectivity were modulated by distal structural changes. This freedom of substitution was utilized to design of a pan-agonist fluorescent probe of a subset of uracil nucleotide-activated hP2YRs.

RADIOLABELED AMINO ACIDS FOR DIAGNOSTIC IMAGING

This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).

Radiolabeled amino acids for diagnostic imaging

This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).

Synthesis of organometallic poly(dendrimer)s by macromonomer polymerization: effect of dendrimer size and structural rigidity on the polymerization efficiency

Two series of first to third generation (G1-G3) oligoether dendrimers, one hearing a shorter spacer chain (C-O) and the other having a longer spacer branch (C-C-C-O) were prepared. Both series of compounds, containing two reactive C≡CH moieties on the dendrimer surface, were used as macromonomers and copolymerized with trans-[Pt(PEt3)2Cl2] to form organometallic poly(dendrimer)s by an outer-sphere-outer-sphere connection strategy. It was found that concentration of monomer used in the polymerization, the dendrimer generation, and, most strikingly, the length of the spacer were key factors that determined the polymerization efficiency. Hence, the structurally more rigid and compact C-O linked dendrimers formed poly(dendrimer)s with a higher degree of polymerization than the structurally less rigid and more bulky C-C-C-O dendrimers. This result was due to the higher tendency to form cyclic oligomers in the latter series of compounds. In addition, the differences in the polymerization efficiency among the three generations of dendrimers could be explained by the gradual decrease of reactive functional group density on the dendrimer surface.

MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME

The present invention provides amide containing macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

The unwanted synthesis of (E,E)-4,21-dimethoxy-2,19-dioxahexacyclo15,18,13,7,120,24>tetratriacontan-3,5,7(35),13,15,17,20,22,24(38),30,32,34,36,39-tetradecaen-12,29-dione and other attempts at the synthesis of ace

Attempts to synthesise acerogenins A and C, diaryl ether type macrocyclic diarylheptanoid constituents of Acer nikoense by macrocyclization involving the formation of (i) a diarylether bond or (ii) one of the bonds in the C7 chain resulted in polymeric pr

Iodo-aryl carbonates for use in methods in radiography

A method for using iodo-aryl carbonates, such as for example, p-iodo-benzyl carbonates, p-iodo-sec-phenethyl carbonates, p-iodo-phenethyl carbonates, p-iodo-phenyl carbonates, 3-(p-iodophenyl)propyl carbonates, 3-(p-iodophenyl)butyl carbonates, 2-(p-iodobenzyl)butyl carbonates and 2-(p-iodobenzyl)-n-hexyl carbonates, to provide radiopaques for various radiography purposes in connection with such techniques as X-ray applications including myelography, salpingography, lymphography and bronchography. The method first comprises selecting a compound generally categorized as a carbonate and having the general formula STR1 wherein R represents an alkyl group having from 1 to 10 carbon atoms and R' represents an iodinated phenyl linked directly to the ester oxygen or through an alkyl chain consisting of 1 to 3 carbon atoms. An effective amount of a pharmaceutically acceptable carbonate, as defined herein, is then placed into the subject body cavity and the particular X-ray or other study performed of this area.

Iodine containing organic carbonates for use as radiographic agents

Iodo-aryl carbonates, such as for example, p-iodo-benzyl carbonates, p-iodo-sec-phenethyl carbonates, p-iodo-phenethyl carbonates, p-iodo-phenyl carbonates, 3-(p-iodophenyl)propyl carbonates, 3-(p-iodophenyl)butyl carbonates, 2-(p-iodobenzyl)butyl carbonates and 2-(p-iodobenzyl)-n-hexyl carbonates, for use as radiographic media in connection with such techniques as x-ray applications including myelography, salpingography, lymphography and bronchography. An effective quantity of iodinated organic carbonate provides x-ray contrast, and the compounds of the invention may be characterized generally as carbonates having the general formula STR1 wherein R represents an alkyl group having from 4 to 10 carbon atoms and R' represents an iodinated phenyl linked to the ester oxygen through an alkyl chain consisting of 1 to 3 carbon atoms.