60075-78-7

Basic information

• Product Name: 3-(p-Iodophenyl)-1-propanol
• Synonyms: 3-(p-Iodophenyl)-1-propanol
• CAS NO: 60075-78-7
• Molecular Formula: C₉H₁₁IO
• Molecular Weight: 262.09
• Mol File: 60075-78-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 301.1°C at 760 mmHg
• Flash Point: 135.9°C
• Appearance: /
• Density: 1.655g/cm³
• Vapor Pressure: 0.000476mmHg at 25°C
• Refractive Index: 1.609
• PKA: 15.03±0.10(Predicted)
• CAS DataBase Reference: 3-(p-Iodophenyl)-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(p-Iodophenyl)-1-propanol(60075-78-7)
• EPA Substance Registry System: 3-(p-Iodophenyl)-1-propanol(60075-78-7)

Safety Data

• Hazardous Substances Data: 60075-78-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11IO/c10-9-5-3-8(4-6-9)2-1-7-11/h3-6,11H,1-2,7H2

Upstream product

• 122-97-4 3-Phenyl-1-propanol 
• 33994-44-4 3-(4-iodophenyl)propionic acid methyl ester 
• 157126-75-5 4-iodobenzenepropanoic acid,ethyl ester 
• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 1643-29-4 3-(4-iodophenyl)propionic acid 
• 122-72-5 3-phenylpropyl acetate 

Downstream Products

• 60075-80-1 Carbonic acid hexyl ester 3-(4-iodo-phenyl)-propyl ester 
• 213264-53-0 5-hydroxy-7-(4-iodophenyl)-1-(4-methoxy-3-methoxymethoxyphenyl)-heptan-3-one 
• 1052138-66-5 3-(4-iodophenyl)propyl methanesulfonate 
• 107399-42-8 3,3'-(1,4-phenylene)dipropanal 
• 63405-68-5 (2E,2'E)-3,3'-(1,4-phenylene)diacrylaldehyde 
• 85356-69-0 1-Iodo-4-(3-iodo-propyl)-benzene 
• 1052119-74-0 C₅₄H₈₈N₄O₁₃ 
• 1052138-68-7 3-[4-(3-azidopropyl)phenyl]pyridine 
• 1000547-83-0 3-(4-pyridin-3-ylphenyl)propylamine 
• 1052138-67-6 1-(3-azidopropyl)-4-iodobenzene 
• 1597430-58-4 C₁₈H₂₂IN₃O₆ 

Relevant articles and documents

One-pot regioselective synthesis of chromanyl(phenyl)-λ3- iodanes: Tandem oxidative cyclization and λ3-iodanation of 3-phenylpropanols

Reaction of 3-phenylpropanol with an activated iodosylbenzene - 18-crown-6 complex [Phl(OH)BF4-18C6] in dichloromethane in the presence of BF3-Et2O afforded directly the 6-chromanyl(phenyl)- λ3-iodane-18C6 compl

4-alkyloxyimino derivatives of uridine-5′-triphosphate: Distal modification of potent agonists as a strategy for molecular probes of P2Y 2, P2Y4, and P2Y6 receptors

Extended N4-(3-arylpropyl)oxy derivatives of uridine-5′-triphosphate were synthesized and potently stimulated phospholipase C stimulation in astrocytoma cells expressing G protein-coupled human (h) P2Y receptors (P2YRs) activated by UTP (P2Y2/4R) or UDP (P2Y6R). The potent P2Y4R-selective N4-(3- phenylpropyl)oxy agonist was phenyl ring-substituted or replaced with terminal heterocyclic or naphthyl rings with retention of P2YR potency. This broad tolerance for steric bulk in a distal region was not observed for dinucleoside tetraphosphate agonists with both nucleobases substituted. The potent N 4-(3-(4-methoxyphenyl)-propyl)oxy analogue 19 (EC50: P2Y2R, 47 nM; P2Y4R, 23 nM) was functionalized for chain extension using click tethering of fluorophores as prosthetic groups. The BODIPY 630/650 conjugate 28 (MRS4162) exhibited EC50 values of 70, 66, and 23 nM at the hP2Y2/4/6Rs, respectively, and specifically labeled cells expressing the P2Y6R. Thus, an extended N4-(3- arylpropyl)oxy group accessed a structurally permissive region on three G q-coupled P2YRs, and potency and selectivity were modulated by distal structural changes. This freedom of substitution was utilized to design of a pan-agonist fluorescent probe of a subset of uracil nucleotide-activated hP2YRs.

Radiolabeled amino acids for diagnostic imaging

This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).