157133-89-6

Upstream product

• 771-99-3 4-phenylpiperidine 
• 407-25-0 trifluoroacetic anhydride 
• 10272-49-8 4-phenylpiperidine hydrochloride 

Downstream Products

• 264608-28-8 4-(1-(2,2,2-trifluoroacetyl)piperidin-4-yl)benzene-1-sulfonyl chloride 
• 160132-86-5 2,2,2-trifluoro-1-[4-(4-nitro-phenyl)-piperidin-1-yl]-ethanone 
• 1070295-21-4 1-(4-(4-(chloromethyl)phenyl)piperidin-1-yl)-2,2,2-trifluoroethanone 
• 1460286-58-1 1-(2-oxo-2-{4-[1-(2,2,2-trifluoro-acetyl)-piperidin-4-yl]phenyl}ethyl)-1H-pyrrole-2-carbonitrile 
• 1460286-06-9 3-(4-piperidin-4-yl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one 
• 1460286-59-2 4-fluoro-1-(2-oxo-2-{4-[1-(2,2,2-trifluoro-acetyl)piperidin-4-yl]phenyl}ethyl)-1H-pyrrole-2-carboxylic acid ethyl ester 
• 1460286-08-1 7-fluoro-3-(4-piperidin-4-yl-phenyl)-2H-pyrrolo[1,2-a]pyrazin-1-one 
• 1460286-10-5 3-[4-(1-methyl-piperidin-4-yl)phenyl]-2H-pyrrolo[1,2-a]pyrazin-1-one 
• 1357182-40-1 benzyl 2-(benzyloxy)-4-(N-(4-(1-((4-cyanophenyl)sulfonyl)piperidin-4-yl)benzyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate 
• 1357182-39-8 benzyl 2-(benzyloxy)-4-(N-(4-(1-(4-cyanobenzoyl)piperidin-4-yl)benzyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)benzoate 
• 1357182-38-7 benzyl 2-(benzyloxy)-4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(1-(pyrimidin-2-yl)piperidin-4-yl)benzyl)acetamido)benzoate 
• 1331747-84-2 C₅₀H₄₈N₄O₆S 
• 1357182-37-6 tert-butyl 4-(4-((N-(3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)-2-(N,4-dimethylphenylsulfonamido)acetamido)methyl)phenyl)piperidine-1-carboxylate 
• 1331747-50-2 4-(2-(N,4-dimethylphenylsulfonamido)-N-(4-(piperidin-4-yl)benzyl)acetamido)-2-hydroxybenzoic acid 

Relevant academic research and scientific papers

ANTIBACTERIAL THIAZOLECARBOXYLIC ACIDS

Compounds of general formula (I), wherein R1, R11, Y, R2, n and A are as defined herein are useful as inhibitors or metallo-β-lactamase (MBL) enzymes and can be used for reducing or removing antibiotic resistance in bacteria.

BICYCLIC PYRAZINONE DERIVATIVES

Compounds of the formula (I) in which R1, X and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous syste

Antagonism of the Stat3-Stat3 Protein Dimer with Salicylic Acid Based Small Molecules

More than 50 new inhibitors of the oncogenic Stat3 protein were identified through a structure-activity relationship (SAR) study based on the previously identified inhibitor S3I-201 (IC50=86μM, Ki>300μM). A key structural feature of

Heterocyclic derivatives as modulators of ion channels

The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

NEW COMPOUNDS AND THEIR USES 707

The present invention relates to isoquinolinone derivatives of formula (I): should be wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

PI3 KINASES

The invention relates to the novel compounds of formula (1), which, due to their pharmaceutical effect as PI3 kinase modulators, are suitable for use in the therapy and treatment of inflammatory or allergic diseases. Examples of these diseases are inflammatory and allergic respiratory diseases, inflammatory diseases of the gastro-intestinal system and of the locomotor apparatus, inflammatory and allergic skin diseases, inflammatory ophthalmic diseases, diseases of the nasal mucosa, inflammatory or allergic autoimmune reactive conditions, or renal inflammations.

Adenosine A2A receptor agonists as antiinflammatory agents

The present invention provides compounds of formula (I): and pharmaceutically acceptable salts and solvates thereof, together with processes for the preparation of, compositions containing, uses of and intermediates used in the preparation of such compounds that have A2a receptor agonist activity.

3-AMIDINOANILINE DERIVATIVES, ACTIVATED BLOOD COAGULATION FACTOR X INHIBITORS, AND INTERMEDIATES FOR PRODUCING BOTH

The present invention relates to a 3-amidinoaniline derivative represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group, a lower alkenyl group etc.; R1 represents a hydrogen atom, a hydroxy group, a lower alkyl group etc.; Y represents a single bond or an oxygen atom; and R2 represents a lower alkyl group or a group represented by the general formula: wherein n represents 1 or 2; and T represents a hydrogen atom or a group represented by the general formula:-C(=NH)-W wherein W represents a lower alkyl group; or a pharmaceutically acceptable salt thereof, which has a potent and selective activated blood coagulation factor X inhibitory activity, and an intermediate for producing both.