157157-76-1Relevant academic research and scientific papers
Stereochemical analysis of chiral amines, diamines, and amino alcohols: Practical chiroptical sensing based on dynamic covalent chemistry
Hassan, Diandra S.,Thanzeel, F. Yushra,Wolf, Christian
, p. 457 - 463 (2020)
Practical chiroptical sensing with a small group of commercially available aromatic aldehydes is demonstrated. Schiff base formation between the electron-deficient 2,4-dinitrobenzaldehyde probe and either primary amines, diamines, or amino alcohols proceeds smoothly in chloroform at room temperature and is completed in the presence of molecular sieves within 2.5 hours. The substrate binding coincides with a distinct circular dichroism signal induction at approximately 330 nm, which can be correlated to the absolute configuration and enantiomeric composition of the analyte. The usefulness of this sensing method is highlighted with the successful sensing of 18 aliphatic and aromatic amines and amino alcohols and five examples showing quantitative %ee determination with good accuracy.
Process for the preparation of β-phenylisoserine and β-lactam and their analogues
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, (2008/06/13)
The present invention relates to new process for the preparation of β-phenylisoserine and its analogues of general formula: STR1 which are particularly useful for preparing taxane derivatives which have remarkable antitumour and antileukaemic activities.
Process for the preparation of β-phenylisoserine and its analogues
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, (2008/06/13)
This invention relates to a method for preparing β-phenylisoserine and analogues thereof having general formula (I) STR1 from an aromatic aldehyde and an α-methylarylamine-S, and through a lactam of general formula (II) as described herein. The acids of g
