157169-68-1

Basic information

• Product Name: METHYL [5-METHYL-2-(4-METHYLPHENYL)-1,3-OXAZOL-4-YL]ACETATE
• Synonyms: METHYL [5-METHYL-2-(4-METHYLPHENYL)-1,3-OXAZOL-4-YL]ACETATE
• CAS NO: 157169-68-1
• Molecular Formula: C₁₄H₁₅NO₃
• Molecular Weight: 245.27
• Mol File: 157169-68-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 368.8±44.0 °C(Predicted)
• Appearance: /
• Density: 1.135±0.06 g/cm3(Predicted)
• PKA: 0?+-.0.26(Predicted)
• CAS DataBase Reference: METHYL [5-METHYL-2-(4-METHYLPHENYL)-1,3-OXAZOL-4-YL]ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL [5-METHYL-2-(4-METHYLPHENYL)-1,3-OXAZOL-4-YL]ACETATE(157169-68-1)
• EPA Substance Registry System: METHYL [5-METHYL-2-(4-METHYLPHENYL)-1,3-OXAZOL-4-YL]ACETATE(157169-68-1)

Safety Data

• Hazardous Substances Data: 157169-68-1(Hazardous Substances Data)

Upstream product

• 439803-74-4 2-(4-methylbenzoylamino)butane-1,4-dioic acid 4-methyl ester 
• 108-24-7 acetic anhydride 
• 30414-53-0 methyl propanoyl acetate 
• 496060-65-2 3-acetyl-3-(4-methylbenzoylamino)propanoic acid methyl ester 
• 105983-77-5 methyl 4-bromo-3-oxopentanoate 
• 619-55-6 para-methylbenzamide 
• 874-60-2 4-methyl-benzoyl chloride 
• 129902-07-4 L-aspartic acid β-methyl ester hydrochloride 

Downstream Products

• 157169-71-6 2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethanol 
• 477541-32-5 methanesulfonic acid 2-(5-methyl-2-p-tolyloxazol-4-yl)ethyl ester 
• 1383439-81-3 C₂₅H₂₉NO₄ 
• 1352085-91-6 3-{2-ethyl-4-[2-(5-methyl-2-p-tolyloxazol-4-yl)ethoxy]phenyl}propanoic acid 
• 496060-66-3 methyl (2S)-2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-2,3-dihydro-1H-inden-1-yl)butanoate 
• 496061-81-5 ethyl 2-((1S)-5-{2-[5-methyl-2-(4-methylphenyl)(1,3-oxazol-4-yl)]ethoxy}indanyl)acetate 
• 439803-80-2 3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile 

Relevant articles and documents

METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE

The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of cognitive disorders based on the ApoE4 genotype of human subjects.

Design and synthesis of 3-(2-ethyl-4-{2-[2-(4-fluorophenyl)- 5-methyloxazol-4-yl]ethoxy}phenyl)propanoic acid: A novel triple-acting PPARα, -γ, and -δ Agonist

The design and synthesis of triple-acting PPARα, -γ, and -δ agonist 3-(2-ethyl-4-{2-[2-(4-fluorophenyl)-5-methyloxazol-4-yl]- ethoxy}phenyl)propanoic acid (1a) is described. The compound possesses a potent triple-acting PPARα, -γ, and -δ agonist profile with an EC50 of 0.029, 0.013, and 0.029 μM, respectively. The synthetic route, involving the synthesis of oxazole rings as the key step, starts from commercially available 3-oxopentanoic acid methyl ester and 3- hydroxyacetophenone to afford the target compound 1 with an overall yield of 32%.

METHOD FOR INCREASING SPECIFIC SURFACE AREA OF SLIGHTLY SOLUBLE DRUG

The preparation method of the powder of which dissolution rate improves is characterized by including of the process that slightly soluble drug having acidic group (e.g., 3-(5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-3,4-dihydronaphthalen-1