1571869-65-2Relevant academic research and scientific papers
Synthesis of Pyrazolo-[4?,3?:5,6]pyrido[2,3-d]pyrimidine-diones Catalyzed by a Nano-sized Surface-Grafted Neodymium Complex of the Tungstosilicate via Multicomponent Reaction
Daraie, Mansoureh,Heravi, Majid M.,Mirzaei, Masoud,Lotfian, Nahid
, (2019/07/09)
An inorganic–organic hybrid based on lanthanide clusters and Keggin type polyoxometalates (POMs) (Na[Nd (pydc-OH)(H2O)4]3}[SiW12O40]) was used the first time as trinuclear catalyst for one pot synthesis of pyrazolo[4??,3?:5,6]pyrido[2,3-d]pyrimidine-diones, via two different four and five-component reactions involving hydrazine hydrate, ethyl acetoacetate, aryl aldehydes, and 6-amino-1,3-dimethyl uracil or barbituric acid with ammonium acetate as alternative materials in green condition. To evaluate potential application of the as-made hybrid in adsorption and separation processes, nitrogen adsorption was performed at 77?K through simulation study. The hybrid catalyst was further characterized via powder X-ray diffraction (PXRD) at room temperature which indicated the good phase purity of the catalyst. The results show that the catalytic activity of the hybrid catalyst has increased relative to each parent component due to the special interaction between Keggin anions and pydc-OH ligands.
A novel and efficient five-component synthesis of pyrazole based pyrido[2,3-d]pyrimidine-diones in water: A triply green synthesis
Heravi, Majid M.,Daraie, Mansoureh
, (2016/05/24)
A novel one pot synthesis of pyrazolo[4' ,3' :5,6]pyrido[2,3-d]pyrimidine-diones, via a five-component reaction, involving, hydrazine hydrate, ethyl acetoacetate, and 1,3-dimethyl barbituric acid, an appropriate aryl aldehydes and ammonium acetate catalyz
Catalytic regioselective synthesis of pyrazole based pyrido[2,3-d] pyrimidine-diones and their biological evaluation
Satasia, Shailesh P.,Kalaria, Piyush N.,Raval, Dipak K.
, p. 1751 - 1758 (2014/03/21)
A new type of biopolymer-based heterogeneous catalyst, cellulose supported acidic ionic liquid (Cell-IL), which was developed earlier in our lab, has been found to be very effective for the regioselective synthesis of pyrazole based pyrido[2,3-d]pyrimidine-diones. Its regioselectivity was confirmed by 1H NMR spectroscopy. All the newly synthesized compounds were characterized by LC-MS, 1H NMR, 13C NMR, IR spectroscopy and elemental analysis. The newly synthesized compounds were evaluated for their in vitro antimalarial activity against Plasmodium falciparum, in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv strain and also for their antibacterial activity against a panel of pathogenic strains of bacteria and fungi. Some of them exhibited excellent activity when compared with first line drugs.
