3206-39-1Relevant academic research and scientific papers
Synthesis and characterization of Fe3O4@THAM-SO3H as a highly reusable nanocatalyst and its application for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives
Faroughi Niya, Homayoun,Hazeri, Nourallah,Maghsoodlou, Malek Taher
, (2020/01/25)
In this work, a new, green and beneficial nanomagnetic catalyst was easily fabricated using sulfuric acid as an acidic group on Fe3O4 nanoparticles coated with tris (hydroxymethyl) aminomethane (THAM). The synthesized catalyst was characterized by FT-IR, TGA/DTG, XRD, TEM, EDS, VSM, and SEM analyses. Next, its catalytic activity was studied for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives. This catalyst has advantages such as high catalytic activity, non-toxicity, easy separation from the reaction mixture using an external magnet and reuses for several times without significantly reducing in its catalytic activity.
Highly efficient synthesis of pyrazolylphosphonate derivatives in biocompatible deep eutectic solvent
Kalla, Reddi Mohan Naidu,Kim, Il
, (2019/05/15)
A straightforward and highly efficient one-pot preparation of biologically interesting pyrazolylphosphonate derivatives via a three-component reaction between pyrazolone or phenylpyrazolone, various aromatic, fused aromatic, heterocyclic, and aliphatic al
Pyrazolone and synthetic method of derivative of pyrazolone
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Paragraph 0037; 0038, (2018/03/26)
The invention relates to pyrazolone and a synthetic method of a derivative of pyrazolone. The method comprises the steps of preparing acetylacetamide with ketene dimer and ammonium hydroxide being rawmaterials in an ammoniation phase; directly adding substituted hydrazine into an ammoniation kettle to be subjected to a condensation reaction in a condensation phase; adopting concentrated hydrochloric acid to adjust the PH to promote proceeding of a ring-closure reaction in a ring-closure phase; using a cleaning solvent to conduct cleaning to obtain a purified product during aftertreatment. According to the synthetic method, a one-pot method is utilized to synthesize a pyrazolone compound free of solvents, since no solvents exist, the separation and purification process of the product are easily carried out, green production of fine chemicals is effectively achieved, the operation is convenient, the reaction time is obviously shortened, high yield of the product with excellent appearance is achieved, the product yield is increased, the product quality is improved, the yield can reach 88%-98%, and the purity can reach 96%-98%; meanwhile, drainage of wastewater is greatly reduced, andthe problems that the environment pollution is caused, the health of the human kind is harmed, and resources are wasted when water serves as a solvent are fundamentally solved.
Green procedure for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles using saccharose
Kangani, Mehrnoosh,Hazeri, Nourallah,Maghsoodlou, Malek Taher,Khandan-Barani, Khatereh,Kheyrollahi, Maryam,Nezhadshahrokhabadi, Fereshteh
, p. 47 - 50 (2015/01/30)
Saccharose was applied as an efficient and homogeneous catalyst for one-pot, four-component synthesis of 1,4-dihydropyrano[2,3-c]pyrazole derivatives from aromatic aldehydes, malononitrile, ethyl acetoacetate and hydrazine monohydrate under thermal solvent-free conditions. This protocol has a considerable number of advantages including mild condition, high yields, operational simplicity, environmentally benign and simple work-up procedures.
Reaction of 6-methyl-2-(2-oxo-2-phenyl-ethylidene)-2,3-dihydropyrimidin- 4(1H)-one with hydrazine and hydroxylamine
Yavolovskii,Grishchuk,Rakipov,Stepanov,Ivanov, Yu. E.,Kamalov
, p. 1487 - 1491 (2013/04/10)
The reaction of 6-methyl-2-(2-oxo-2-phenylethylidene)-2,3-dihydropyrimidin- 4(1H)-one and of its nitrosation product with hydroxylamine stops at the stage of forming the corresponding oximes. The reaction of 6-methyl-2-(2-oxo-2- phenylethylidene)-2,3-dihydropyrimidin-4(1H)-one with hydrazine yields a mixture of 3-amino-5-phenylpyrazole and 3-methyl-2-pyrazolin-5-one in 71 and 62% yields, respectively. The ketoxime is used in the synthesis of a series of imidazole N(3)-oxides substituted at the 1, 4, and 5 positions of the imidazole ring.
Conversions of coumarins accompanied by intermediate opening and recyclization of the lactone ring. 2. Study of the interaction of malonic acid hydrazide and amide derivatives with 3-acyl(3-cyano, 3-ethoxycarbonyl)coumarins
Nemeryuk,Dimitrova,Anisimova,Sedov,Solov'eva,Traven
, p. 1255 - 1266 (2007/10/03)
Reaction between the N,N′-diisopropylidene and N,N′-diacetyl derivatives of malonic acid dihydrazide and 3-acyl(3-cyano, 3-ethoxycarbonyl) coumarins under the conditions of the Michael reaction lead to the formation of N′-isopropylidene and N′-acetyl derivatives of coumarin-3-carboxylic acid hydrazide. Ethoxycarbonylacethydrazide reacts in an analogous manner. Special features have been studied of the interaction of malonic acid amide derivatives with unsubstituted coumarin and with coumarins containing electron-withdrawing groupings in position 3 of the ring. 2005 Springer Science+Business Media, Inc.
Synthesis and antiamoebic activity of 3,7-dimethyl-pyrazolo[3,4-e][1,2,4] triazin-4-yl thiosemicarbazide derivatives
Singh, Shailendra,Husain, Kakul,Athar, Fareeda,Azam, Amir
, p. 255 - 262 (2007/10/03)
A series of 3,7-dimethyl-pyrazolo[3,4-e][1,2,4]triazin-4-yl thiosemicarbazide derivatives 3-22 were prepared and evaluated in vitro against HM1:1MSS strain of Entamoeba histolytica, to identify the compounds for antiamoebic activity. They exhibited antiamoebic activity in the range (IC 50 = 0.81-7.31 μM). The results were compared to the activity of known drug metronidazole. It is inferred from the in vitro studies that the compounds 10, 11, 17 and 18 were found to be significantly better inhibitors of E. histolytica since IC50 values in the μM range elicited by these compounds are much lower than metronidazole. Besides, compounds 11 and 17 have shown the most promising antiamoebic activity (IC50 = 0.81 μM of 11, IC50 = 0.84 μM of 17 versus IC50 = 1.81 μM of metronidazole). The study suggests the possibility of developing triazine analogues as potential drug candidates for antiamoebic activity.
