1571900-72-5Relevant academic research and scientific papers
Towards the diastereoselective synthesis of derivative of 11′-epi-brevipolide H
Kumaraswamy, Gullapalli,Jayaprakash, Neerasa,Rambabu, Dasa,Ganguly, Aniban,Banerjee, Rajkumar
, p. 1793 - 1803 (2014/03/21)
An efficient diastereoselective synthesis of brevipolide H derivative is described. The approach features the use of (i) catalytic asymmetric transfer hydrogenation, (ii) hydroxyl-directed cyclopropanation, and (iii) substrate-controlled catalytic epoxidation and ring-closing metathesis. Remarkably, in this convergent synthesis process, stereogenic centers were installed through catalytic reactions with high stereocontrol, which greatly facilitates the synthesis of stereo-divergent derivatives.
