1572040-03-9Relevant academic research and scientific papers
Rhodium-Catalyzed Enantioselective Defluorinative α-Arylation of Secondary Amides
Jang, Young Jin,Rose, Daniel,Mirabi, Bijan,Lautens, Mark
supporting information, p. 16147 - 16151 (2018/11/23)
We exploited the reactivity of an electronically biased Michael acceptor to perform a defluorinative α-arylation reaction using a chiral diene(L*)-rhodium catalyst. Through this methodology, we are able to obtain various secondary amides, containing a tertiary α-stereocenter and a β,γ-unsaturated gem-difluoro olefin, with excellent enantioselectivities. This methodology addresses the limitations of the previously described α-arylation methods to construct stereo-labile tertiary α-stereocenters. Further investigation of the reaction via in situ 19F NMR monitoring suggests that the formation of the product leads to the inhibition of the active rhodium catalyst.
A second-generation ligand for the enantioselective rhodium-catalyzed addition of arylboronic acids to alkenylazaarenes
Roy, Iain D.,Burns, Alan R.,Pattison, Graham,Michel, Boris,Parker, Alexandra J.,Lam, Hon Wai
supporting information, p. 2865 - 2868 (2014/03/21)
A 2,4,6-trialkylanilide-containing chiral diene has been identified as a superior ligand for the enantioselective rhodium-catalyzed arylation of alkenylazaarenes with arylboronic acids.
