1572180-89-2Relevant academic research and scientific papers
Copper-mediated cross-coupling-cyclization-oxidation: A one-pot reaction to construct polysubstituted pyrroles
Liu, Pei,Liu, Jin-Ling,Wang, Heng-Shan,Pan, Ying-Ming,Liang, Hong,Chen, Zhen-Feng
supporting information, p. 4795 - 4798 (2014/05/06)
A novel and efficient procedure for the synthesis of polysubstituted pyrroles has been developed in this work. The polysubsituted pyrroles were synthesized directly from terminal alkenes, amines and β-keto esters through cross-coupling-cyclization-oxidation in the presence of a catalytic amount of cuprous chloride. This method provides a one-pot synthesis route from terminal alkenes to polysubstituted pyrroles for the first time and opens a new area in cuprous catalysis. The Royal Society of Chemistry 2014.
