1572185-50-2

Usage

Uses

Used in Pharmaceutical Synthesis:
2-bromo-4-fluoro-6-methylphenol is utilized as an intermediate in the synthesis of pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to advancements in medicinal chemistry.
Used in Agrochemical Production:
In the agrochemical industry, 2-bromo-4-fluoro-6-methylphenol serves as a key intermediate for the production of various agrochemicals. Its incorporation into these products can enhance their effectiveness in protecting crops from pests and diseases.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-bromo-4-fluoro-6-methylphenol is employed in the creation of complex organic molecules. Its presence in these reactions can lead to the formation of new compounds with diverse applications in various fields.
Used in Dye and Pigment Manufacturing:
2-bromo-4-fluoro-6-methylphenol is also used in the production of dyes and pigments. Its chemical properties enable the creation of vibrant and stable colorants for use in various industries, including textiles, plastics, and printing.
Used in Industrial and Medical Applications:
Due to its antimicrobial and antifungal properties, 2-bromo-4-fluoro-6-methylphenol finds use in a range of industrial and medical applications. It can be incorporated into products to prevent the growth of harmful microorganisms, ensuring cleanliness and safety in various settings.
Safety Precautions:
Given the potential hazards associated with 2-bromo-4-fluoro-6-methylphenol, it is crucial to handle and store 2-bromo-4-fluoro-6-methylphenol according to appropriate safety guidelines. This includes using personal protective equipment, working in well-ventilated areas, and following proper disposal methods to minimize risks to human health and the environment.

Upstream product

• 452-72-2 4-fluoro-2-methylphenol 

Downstream Products

• 245762-35-0 5-fluoro-2,3-dihydrobenzofuran 
• 1572185-25-1 2-(4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide 
• 1572185-24-0 methyl 2-(4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetate 
• 1572185-47-7 4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenol 
• 1572184-66-7 (E)-N’-((1H-indol-4-yl)methylene)-2-(4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide 
• 1572184-65-6 (E)-N’-((1H-indol-6-yl)methylene)-2-(4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide 
• 1572185-31-9 4-fluoro-2-(furan-3-yl)-6-methylphenol 

Relevant academic research and scientific papers

Preparation method of 2-bromo-4-fluoro-6-methylphenol

The invention discloses a preparation method of 2-bromo-4-fluoro-6-methylphenol, and belongs to the technical field of fine chemical engineering. The preparation method of 2-bromo-4-fluoro-6-methylphenol comprises the following steps of: (1) diazotization hydrolysis reaction: carrying out diazotization hydrolysis reaction on 2-methyl-4-fluoroaniline to obtain 2-methyl-4-fluorophenol; and (2) bromination reaction: carrying out bromination reaction on the 2-methyl-4-fluorophenol prepared in the step (1) to prepare the 2-bromo-4-fluoro-6-methylphenol. According to the method, nitrosyl sulfuric acid is adopted as an acylation reagent, waste acid obtained after diazotization hydrolysis is completed does not contain salt, acidic wastewater is easy to treat, and industrial production is facilitated; bromine used in the bromination reaction is greatly reduced, and the technological process is more environmentally friendly.

Preparation method of 2- bromo -4- fluoro -6- methyl phenol (by machine translation)

2 - (,) The process for preparing .2 -methylnitrobenzene, (:) by subjecting 1 fluorine - 2 2-methylnitrobenzene prepared in step (:) to a reduction reaction 4 - to prepare; fluorine - 2 2-methylphenol. 2. The method comprises the following steps :) of nitrosation reaction 1 (4 -) diazo hydrolysis. 4 - g - 2 2-methylphenol prepared by the following steps: The process of the present invention, is simple 3% by diazotization reaction: to prepare 3 the 2 fluorine - 2 2-methylphenol obtained in step (4 -) by means of a reduction reaction step (4 -) to form 4 - fluorine. 2 2 (4 2 -)-methylphenol prepared by the same step as a process. for the preparation of fine chemical products by 2 - means of the bromination reaction step of the preparation, method as shown in the following step (. a).]) The method comprises the following steps: (a)) diazo reaction : (by machine translation)

Redox-Neutral Coupling between Two C(sp3)?H Bonds Enabled by 1,4-Palladium Shift for the Synthesis of Fused Heterocycles

The intramolecular coupling of two C(sp3)?H bonds to forge a C(sp3)?C(sp3) bond is enabled by 1,4-Pd shift from a trisubstituted aryl bromide. Contrary to most C(sp3)?C(sp3) cross-dehydrogenative couplings, this reaction operates under redox-neutral conditions, with the C?Br bond acting as an internal oxidant. Furthermore, it allows the coupling between two moderately acidic primary or secondary C?H bonds, which are adjacent to an oxygen or nitrogen atom on one side, and benzylic or adjacent to a carbonyl group on the other side. A variety of valuable fused heterocycles were obtained from easily accessible ortho-bromophenol and aniline precursors. The second C?H bond cleavage was successfully replaced with carbonyl insertion to generate other types of C(sp3)-C(sp3) bonds.