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1,4-PBIT DIHYDROBROMIDE, also known as 1,4-Phthalazinedione dihydrobromide, is a chemical compound with potent inhibitory properties against specific isoforms of Nitric Oxide Synthase (NOS) enzymes. It is characterized by its ability to selectively inhibit human iNOS (inducible NOS) and nNOS (neuronal NOS) with high affinity, while showing less inhibition towards human eNOS (endothelial NOS). The compound's structure and properties make it a promising candidate for various applications in the pharmaceutical and medical fields.

157254-60-9

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157254-60-9 Usage

Uses

Used in Pharmaceutical Research:
1,4-PBIT DIHYDROBROMIDE is used as a research tool for studying the role of NOS enzymes in various physiological and pathological processes. Its high selectivity for iNOS and nNOS makes it valuable in understanding the specific functions and regulation of these enzymes in the body.
Used in Neurological Applications:
1,4-PBIT DIHYDROBROMIDE is used as a therapeutic agent for neurological disorders characterized by excessive nNOS activity. By inhibiting nNOS, the compound may help in reducing the overproduction of nitric oxide, which is often associated with neurodegenerative diseases and other neurological conditions.
Used in Inflammation and Immune Response Applications:
1,4-PBIT DIHYDROBROMIDE is used as an anti-inflammatory agent, targeting iNOS, which is involved in the production of nitric oxide during inflammatory responses. Inhibition of iNOS by 1,4-PBIT DIHYDROBROMIDE may help in reducing inflammation and modulating the immune system.
Used in Cardiovascular Applications:
1,4-PBIT DIHYDROBROMIDE is used as a potential therapeutic agent for cardiovascular diseases, where iNOS inhibition may help in reducing the harmful effects of nitric oxide overproduction, such as endothelial dysfunction and vascular inflammation.

Check Digit Verification of cas no

The CAS Registry Mumber 157254-60-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,2,5 and 4 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 157254-60:
(8*1)+(7*5)+(6*7)+(5*2)+(4*5)+(3*4)+(2*6)+(1*0)=139
139 % 10 = 9
So 157254-60-9 is a valid CAS Registry Number.

157254-60-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[4-(2-carbamimidoylsulfanylethyl)phenyl]ethyl carbamimidothioate,dihydrobromide

1.2 Other means of identification

Product number -
Other names 1,4-PBIT dihydrobromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:157254-60-9 SDS

157254-60-9Downstream Products

157254-60-9Relevant academic research and scientific papers

Anti-cancer compositions and methods

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, (2011/09/15)

Anti-cancer compositions and methods are described including one or more compounds having the structural formula I: where R is phenyl, where R1 is (CH2)n—Se—C(═NH)—NH2, where R2 is (CH2)n—Se—C(═NH)—NH

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