157282-75-2

Upstream product

• 54752-30-6 2-p-methylbenzylidene-1-tetralone 
• 17356-08-0 thiourea 
• 104-87-0 4-methyl-benzaldehyde 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Downstream Products

• 157282-76-3 7-p-Tolyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one 
• 157282-86-5 9-[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-7-p-tolyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one 
• 157282-87-6 9-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-7-p-tolyl-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one 
• 157282-85-4 7-p-Tolyl-9-[1-p-tolyl-meth-(E)-ylidene]-5,7-dihydro-6H-10-thia-7a,11-diaza-cyclopenta[b]phenanthren-8-one 

Relevant academic research and scientific papers

Base-mediated one-pot synthesis of 3,4,5,6-tetrahydro-4-substituted benzo[h]quinazoline-2(1H)-thione derivatives and evaluation of their antioxidant activity

One-pot three-component Beginelli-like reactions of a ketone 1, an aryl aldehyde 2, and thiourea 3 in the presence of sodium hydroxide are described. In this reaction, 3,4,5,6-tertrahydro-4-substituted quinazoline-2(1H)-thione derivatives 4a–h were obtain

FeCl3·6H2O/TMSBr-catalyzed rapid synthesis of dihydropyrimidinones and dihydropyrimidinethiones under microwave irradiation

An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl3 6H2O TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up, thus affording a versatile method for the synthesis of dihydropyrimidinones and dihydropyrimidinethiones.

Preparation system and preparation method of benzo quinazolinone derivative

The invention discloses a preparation system and preparation method of a benzo quinazolinone derivative and belongs to the technical field of organic synthesis. The preparation system of the benzo quinazolinone derivative comprises a reactor, an ultrasonic-assisted reaction device, an ice-water bath cooling device, a suction filtration device, a washing device and a vacuum drying device, wherein the ultrasonic-assisted reaction device, the ice-water bath cooling device, the suction filtration device, the washing device and the vacuum drying device are sequentially arranged. Aromatic aldehyde, alpha-tetralone and urea or thiourea are taken as reaction raw materials and are catalyzed under the catalytic action of an acidic ionic liquid catalyst and under the ultrasonic-assisted action to prepare the benzo quinazolinone derivative. By adopting the technical scheme, the catalyst is relatively small in dosage and loss, and can be recycled for multiple times, the preparation system is high in raw material utilization rate and short in reaction time and a product is simple and convenient to purify.

Catalytic application of task specific ionic liquid on the synthesis of benzoquinazolinone derivatives by a multicomponent reaction

Benzoquinazolin-2-one derivatives were synthesized by using a catalytic amount of task specific ionic liquid, [1-methyl-3-(4-sulfobutyl)imidazolium-4- methylbenzenesulfonate] through a one-pot multicomponent Biginelli reaction of α-tetralone, aldehyde, and urea/thiourea in excellent yields within a short reaction time. Mechanism studies suggest that the reaction proceeds through iminium intermediate and C2-H of the TSIL plays a major role on its catalytic activity. The catalyst has been reused four times without any significant loss in catalytic activity. Large scale reaction by using this TSIL suggests the applicability of this methodology for bulk synthesis of quinazolinone derivatives.

Efficient ionic liquid-catalysed synthesis and antimicrobial studies of 4,6-diaryl- and 4,5-fused pyrimidine-2-thiones

One-pot three-component condensation of aromatic ketones (1-tetralones, acetophenones, indane-1,3-dione), substituted aromatic aldehydes and thiourea in the presence of N-methylpyridinium tosylate under solvent free conditions at 100-110 °C for 2-4 h afforded tetrahydrobenzo[h]quinazoline-2-thiones, pyridimidine-2-thiones and indeno-pyrimidine-2-thiones in excellent yields. All synthesised thiones were screened for their antimicrobial activities.

A novel and efficient one-pot method to Biginelli-like scaffolds

A novel and efficient one-pot method for the preparation of fused ring 3,4-dihydropyrimidin-2(1H)-ones and thiones from cyclocondensation of aldehydes, cyclic ketones and urea or thiourea using a catalytic amount of cupric chloride under mild conditions reaction is described. This new method has the advantage to give high yields, to be completed in short reaction times and simple product isolation procedure.

Heterocyclic systems containing bridgehead nitrogen atom: Part LXXV - Syntheses of thiazolobenzoquinazolines and thiazinobenzoquinazolines

2-Arylidenetetralin-1-ones (1a-c) on condensation with thiourea give 4-aryl-3,4,5,6-tetrahydrobenzoquinazoline-2(1H)-thiones (2a-c) which on reaction with chloroacetic acids, α- and β-halopropionic acids afford 5-aryl-2,3,6,7-tetrahydro-3-oxo-5H-thiazo