1572927-91-3

Upstream product

• 1450620-16-2 tert-butyl (5-(chlorosulfonyl)-2-pyridinyl)carbamate 
• 1572928-72-3 tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(methoxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate 
• 220731-04-4 5-amino-2-tert-butyloxycarbonylaminopyridine 
• 161117-88-0 (tert-butoxy)-N-(5-nitro(2-pyridyl))carboxamide 
• 1450620-15-1 4-benzyl 1-tert-butyl (2S)-2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate 
• 1450620-14-0 4-benzyl 1-tert-butyl 2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate 
• 1361224-50-1 benzyl 3-(propan-1-yn-1-yl)piperazine-1-carboxylate 
• 1361224-49-8 benzyl (2-((tert-butoxycarbonyl)amino)ethyl)(2-oxo-3-pentyn-1-yl)-carbamate 
• 1239766-85-8 2-(4-bromophenyl)-2-(trifluoromethyl)oxirane 
• 1572928-04-1 tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2-(trifluoromethyl)-2-oxiranyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate 
• 1572928-03-0 tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)phenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate 
• 1450620-98-0 (2S)-1-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-2-(1-propyn-1-yl)piperazine 
• 1450620-77-5 benzyl (3S)-4-(4-(2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolan-4-yl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate 
• 1450620-70-8 4-(4-bromophenyl)-2,2-dimethyl-4-(trifluoromethyl)-1,3-dioxolane 

Relevant academic research and scientific papers

TRICYCLIC ALKYNES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN

The present invention relates to tricyclic alkyne compounds of formula I that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where gluco