157301-82-1

Basic information

• Product Name: 4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile
• Synonyms: 4-Chlor-8-(trifluormethyl)chinolin-3-carbonitril
• CAS NO: 157301-82-1
• Molecular Formula: C₁₁H₄ClF₃N₂
• Molecular Weight: 256.61
• Mol File: 157301-82-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 349.2°C at 760 mmHg
• Flash Point: 165°C
• Density: 1.5g/cm³
• Vapor Pressure: 4.78E-05mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile(157301-82-1)
• EPA Substance Registry System: 4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile(157301-82-1)

Safety Data

• Hazardous Substances Data: 157301-82-1(Hazardous Substances Data)

Upstream product

• 71083-67-5 4-hydroxy-8-(trifluoromethyl)quinoline-3-carbonitrile 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Downstream Products

• 854771-66-7 4-(3-aminophenyl)-8-(trifluoromethyl)quinoline-3-carbonitrile 
• 854771-69-0 4-(3-Hydroxyphenyl)-8-(Trifluoromethyl)Quinolin E-3-Carbonitrile 

Relevant articles and documents

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood-brain penetration

A series of quinoline-3-carboxamide containing sulfones was prepared and found to have good binding affinity for LXRβ and moderate binding selectivity over LXRα. The 8-Cl quinoline analog 33 with a high TPSA score, displayed 34-fold binding selectivity for LXRβ over LXRα (LXRβ IC50 = 16 nM), good activity for inducing ABCA1 gene expression in a THP macrophage cell line, desired weak potency in the LXRα Gal4 functional assay, and low blood-brain barrier penetration in rat.