1573116-91-2Relevant academic research and scientific papers
Intramolecular aminocyanation of alkenes by cooperative palladium/boron catalysis
Miyazaki, Yosuke,Ohta, Naoki,Semba, Kazuhiko,Nakao, Yoshiaki
supporting information, p. 3732 - 3735 (2014/04/03)
A cooperative palladium/triorganoboron catalyst to accomplish the intramolecular aminocyanation of alkenes through the cleavage of N-CN bonds is reported. 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos) is found to be crucial as a ligand for palladium to effectively catalyze the transformation with high chemo- and regioselectivity. A range of substituted indolines and pyrrolidines with both tetra- or trisubstituted carbon and cyano functionalities are readily furnished by the newly developed cyanofunctionalization reaction. A preliminary example of enantioselective aminocyanation is also described.
