1191268-97-9

Basic information

• Product Name: C₂₃H₂₉ClOSi
• Synonyms: C₂₃H₂₉ClOSi
• CAS NO: 1191268-97-9
• Molecular Weight: 385.021
• Mol File: 1191268-97-9.mol

Chemical Properties

• Boiling Point: 440.5±45.0 °C(Predicted)
• Density: 1.04±0.1 g/cm3(Predicted)
• CAS DataBase Reference: C₂₃H₂₉ClOSi(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₉ClOSi(1191268-97-9)
• EPA Substance Registry System: C₂₃H₂₉ClOSi(1191268-97-9)

Safety Data

• Hazardous Substances Data: 1191268-97-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
C₂₃H₂₉ClOSi is used as an intermediate in the synthesis of Eribulin (E615203) for its role in the development of anticancer drugs. Eribulin is a microtubule dynamics inhibitor that has been shown to be effective against various types of cancer, including solid malignancies. The compound's unique structure allows it to be a crucial component in the synthesis process, contributing to the overall effectiveness of the final drug product.
Used in Cancer Treatment:
C₂₃H₂₉ClOSi is used as a key component in the development of Eribulin, an anticancer agent that targets microtubule dynamics. This disruption in microtubule dynamics leads to the inhibition of cell division and ultimately results in the death of cancer cells. Eribulin has been found to be effective against a range of solid malignancies, making C₂₃H₂₉ClOSi an essential part of the fight against cancer.

Upstream product

• 606942-43-2 (S)-7-((tert-butyldiphenylsilyl)oxy)hept-1-yn-4-ol 
• 127793-62-8 4-((tert-butyldiphenylsilyl)oxy)butanal 
• 1191269-06-3 (±)-7-((tert-butyldiphenylsilyl)oxy)hept-1-yn-4-ol 
• 132047-92-8 tert-butyl(pent-4-en-1-yloxy)diphenylsilane 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 1583253-13-7 C₁₆H₁₉BrClNO₃ 
• 1583253-32-0 C₂₉H₃₄BrClO₁₀ 
• 1583253-09-1 C₇H₁₁ClO 
• 157322-47-9 3-((2S,5S)-5-((3R,5R)-3-hydroxy-6-iodo-5-methylhept-6-en-1-yl)-4-methylenetetrahydrofuran-2-yl)propyl pivalate 
• 1191268-95-7 (R)-tert-butyl((4-chloro-6-iodohept-6-en-1-yl)oxy)diphenylsilane 

Relevant articles and documents

Chemoenzymatic process for the preparation of (S)-7-((tert-butyldiphenylsilyl)oxy)hept-1-yn-4-ol in a continuous packed-bed reactor, a key intermediate for eribulin synthesis

A practical chemoenzymatic process has been developed for the preparation of optically pure (S)-7-((tertbutyldiphenylsilyl) oxy)hept-1-yn-4-ol, (S)-4. This was prepared via enantioselective acylation of racemic homopropargylic alcohol (+/-)-4 catalyzed by

Catalytic enantioselective Cr-Mediated propargylation: application to halichondrin synthesis

A catalytic enantioselective propargylation In the presence of 10 mol % of Cr catalyst prepared from Cr(III) bromide and (R)-sulfonamide E furnishes homopropargyl alcohol 8 In 78% yield with 90% ee. Coupled with the workup based on Amano-llpase, this meth