157327-69-0

Upstream product

• 153610-33-4 (-)-(1S,2R,1'S)-1-1',2'-dihydroxyethyl-2-1-hydroxy-1-methylethyl-1-methylcyclobutane 
• 153610-32-3 (-)-(1R,4S,5S)-5-methyl-4-pivaloyloxymethyl-3-oxabicyclo<3.2.0>heptan-2-one 
• 42908-73-6 4-fluorophenyl chlorothionoformate 
• 157327-68-9 (-)-(1R,5S,6S)-5-hydroxy-2,2,6-trimethyl-3-oxabicyclo<4.2.0>octane 

Relevant academic research and scientific papers

Diastereoselective and highly efficient radical approach to (1S,6R) and (1R,6S)-2,2,6-trimethyl-3-oxabicyclo [4.2.0]octadecane, key intermediates in the synthesis of (+) and (-)-grandisol

The pure enantiomers (1S,6R) and (1R,6S)-2,2,6-trimethyl-3-oxabicyclo[4.2.0]octadecane, key intermediates in the synthesis of (+) and (-)-grandisol are prepared by a highly efficient radical deoxygenation under mild conditions of secondary hydroxyl groups

Highly efficient and diastereoselective approaches to (+)- and (-)-grandisol

Two new routes to (+)-grandisol and three new routes to (-)-grandisol are described. All of them are highly efficient and diastereoselective. The common starting material is an easily available homochiral butenolide.