Diastereoselective and highly efficient radical approach to (1S,6R) and (1R,6S)-2,2,6-trimethyl-3-oxabicyclo [4.2.0]octadecane, key intermediates in the synthesis of (+) and (-)-grandisol

Article abstract of DOI:10.1016/S0040-4039(00)77178-4

The pure enantiomers (1S,6R) and (1R,6S)-2,2,6-trimethyl-3-oxabicyclo[4.2.0]octadecane, key intermediates in the synthesis of (+) and (-)-grandisol are prepared by a highly efficient radical deoxygenation under mild conditions of secondary hydroxyl groups