157329-89-0

Basic information

• Product Name: 2-Bromo-6-Chloro-4-Picoline
• Synonyms: 2-Bromo-6-Chloro-4-Picoline;2-bromo-6-chloro-4-methylpyridine
• CAS NO: 157329-89-0
• Molecular Formula: C₆H₅BrClN
• Molecular Weight: 206.4676
• Product Categories: Pyridine
• Mol File: 157329-89-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 262℃
• Flash Point: 112℃
• Appearance: /
• Density: 1.624
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.22±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-6-Chloro-4-Picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-Chloro-4-Picoline(157329-89-0)
• EPA Substance Registry System: 2-Bromo-6-Chloro-4-Picoline(157329-89-0)

Safety Data

• Hazardous Substances Data: 157329-89-0(Hazardous Substances Data)

Usage

Description

2-Bromo-6-Chloro-4-Picoline, a chemical compound with the molecular formula C6H4BrClN, is an important reagent in the field of organic synthesis. It is known for its aromatic properties, which are derived from a pyridine ring structurally incorporated with bromine and chlorine atoms. This specialized compound typically appears as a clear, colorless to light yellow liquid. Due to its reactivity and potential hazards, handling of this chemical requires appropriate safety measures. It is commonly used in a laboratory setting for research and development.

Uses

Used in Organic Synthesis:
2-Bromo-6-Chloro-4-Picoline is used as a reagent for various organic synthesis processes. Its unique structure with bromine and chlorine atoms on the pyridine ring allows for versatile chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Research and Development:
In a laboratory setting, 2-Bromo-6-Chloro-4-Picoline is used as a research compound to explore its properties and potential applications. Scientists and researchers utilize this compound to investigate its reactivity, stability, and interactions with other chemicals, which can lead to the discovery of new compounds and materials.
Used in Pharmaceutical Industry:
2-Bromo-6-Chloro-4-Picoline is used as a building block in the synthesis of pharmaceutical compounds. Its unique structure and reactivity make it a promising candidate for the development of new drugs and therapeutic agents. Researchers in the pharmaceutical industry use this compound to create novel molecules with potential medicinal properties.
Used in Chemical Industry:
In the chemical industry, 2-Bromo-6-Chloro-4-Picoline is used as an intermediate in the production of various chemical products. Its versatility in organic synthesis allows for the creation of a wide range of chemical compounds, which can be used in various applications, such as dyes, pigments, and specialty chemicals.

InChI:InChI=1/C6H5BrClN/c1-4-2-5(7)9-6(8)3-4/h2-3H,1H3

Upstream product

• 3678-62-4 2-chloro-4-picoline 
• 108-89-4 picoline 

Downstream Products

• 209858-74-2 2-cyano-6-chloro-4-methyl pyridine 
• 1206476-61-0 (6-chloro-4-methyl-pyridin-2-yl)-(4-trifluoromethyl-phenyl)-amine 
• 1206476-03-0 4-methyl-2,6-bis-(4-trifluoromethylphenyl)-pyridine 
• 951231-30-4 2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyridine 

Relevant articles and documents

Side-chain retention during lithiation of 4-picoline and 3,4-lutidine: Easy access to molecular diversity in pyridine series

The first direct ring-selective lithiation of 4-picoline and 3,4-lutidine has been achieved through the use of BuLi/LiDMAE aggregates to prevent the usual side-chain metallation. Several functionalities have been introduced at the C-2, C-6 and C-5 positions by ring-selective sequential lithiation, opening a simple and fast route to polysubstituted pyridine building blocks. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.