209858-74-2

Basic information

• Product Name: 6-Chloro-4-methylpicolinonitrile
• Synonyms: 6-Chloro-4-methylpicolinonitrile;6-Chloro-4-Methyl-2-pyridinecarbonitrile;6-Chloro-4-methylpyridine-2-carbonitrile
• CAS NO: 209858-74-2
• Molecular Formula: C₇H₅ClN₂
• Molecular Weight: 152.583
• Mol File: 209858-74-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 283.6 °C at 760 mmHg
• Flash Point: 125.3 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 0.00314mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: 2-8°C
• PKA: -4.97±0.10(Predicted)
• CAS DataBase Reference: 6-Chloro-4-methylpicolinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-4-methylpicolinonitrile(209858-74-2)
• EPA Substance Registry System: 6-Chloro-4-methylpicolinonitrile(209858-74-2)

Safety Data

• Hazardous Substances Data: 209858-74-2(Hazardous Substances Data)

Usage

General Description

6-Chloro-4-methylpicolinonitrile, also known by its chemical formula C7H6ClN2, is a derivative of picolinonitrile. It is a colorless to pale yellow crystalline powder that is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. This chemical compound is primarily used as a building block in the production of pyridine-based drugs and pesticides. Its versatile reactivity makes it a valuable tool for organic synthesis, and it is commonly utilized in research and development within the pharmaceutical and agricultural industries. Additionally, 6-Chloro-4-methylpicolinonitrile has applications in the production of dyes and pigments, as well as in the creation of specialty chemicals. As with any chemical compound, proper handling and storage are essential to ensure safety and prevent potential hazards.

InChI:InChI=1/C7H5ClN2/c1-5-2-6(4-9)10-7(8)3-5/h2-3H,1H3

Upstream product

• 52313-61-8 2-chloro-4-methylpyridin-N-oxide 
• 170487-39-5 2-cyano-4-methylpyridine-1-oxide 
• 1620-76-4 2-Cyano-4-methylpyridin 
• 3678-62-4 2-chloro-4-picoline 
• 773837-37-9 sodium cyanide 
• 157329-89-0 2-bromo-6-chloro-4-methylpyridine 

Downstream Products

• 324028-95-7 6-chloro-4-methylpyridine-2-carboxylic acid 

Relevant articles and documents

Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3 H-1,2,4-triazol-3-one, by Fragment-Based Drug Design

This publication details the successful use of FBDD (fragment-based drug discovery) principles in the invention of a novel covalent Bruton's tyrosine kinase inhibitor, which ultimately became the Takeda Pharmaceuticals clinical candidate TAK-020. Describe

SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

Substituted cyclopropyl compounds of the formula I: are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as well. The compounds are useful as agonists of the g-protein coupled receptor GPR-119.

6-(Nonsubstituted or substituted) phenoxy picolinic acids, process of preparing the same, and agricultural/horticultural germicides containing the same

An agricultural or horticultural fungicide containing 6-(unsubstituted or substituted) phenoxy picolinic acid represented by the general formula (I), as an effective ingredient. wherein R is a halogen atom, a C1to C4alkyl group, a C1to C4haloalkyl group, a C1to C4alkoxy group, a C1to C4haloalkoxy group, a C1to C4alkylthio group, a C1to C4alkylamino group, a di(C1to C4alkyl)amino group or a C7to C8aralkyl(C1to C4alkyl)amino group; n2is an integer of 0 to 3; Y is a C1to C4alkyl group, a C1to C4haloalkyl group, a C1to C4alkoxy group, a C1to C4haloalkoxy group, a C1to C4alkylthio group, a C1to C4haloalkylthio group or a halogen atom; and m is an integer of 0 to 5, and when m and n2are not less than 2, Rs and Ys may be the same or different, respectively. The compound is useful as an effective ingredient of agricultural or horticultural fungicides.