157396-11-7

Basic information

• Product Name: 7-(4-chlorophenylthio)-6,7-dihydro-1-(phenylsulfonyl)-1H-indol-4(5H)-one
• Synonyms: 7-(4-chlorophenylthio)-6,7-dihydro-1-(phenylsulfonyl)-1H-indol-4(5H)-one
• CAS NO: 157396-11-7
• Molecular Weight: 417.937
• Mol File: 157396-11-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-(4-chlorophenylthio)-6,7-dihydro-1-(phenylsulfonyl)-1H-indol-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-chlorophenylthio)-6,7-dihydro-1-(phenylsulfonyl)-1H-indol-4(5H)-one(157396-11-7)
• EPA Substance Registry System: 7-(4-chlorophenylthio)-6,7-dihydro-1-(phenylsulfonyl)-1H-indol-4(5H)-one(157396-11-7)

Safety Data

• Hazardous Substances Data: 157396-11-7(Hazardous Substances Data)

Upstream product

• 157396-13-9 ethyl 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoate 
• 146564-01-4 ethyl 4-chloro-4-(4-chlorophenylthio)butanoate 
• 16851-82-4 N-phenylsulfonylpyrrole 
• 157396-14-0 4-(4-chlorophenylthio)-4-(1-phenylsulfonyl-1H-pyrrol-2-yl)butanoyl chloride 

Downstream Products

• 146564-00-3 1‐(benzenesulfonyl)‐4‐methoxy‐1H‐indole 
• 146564-05-8 1-Benzenesulfonyl-7-(4-chloro-phenylsulfanyl)-4-methyl-4,5,6,7-tetrahydro-1H-indol-4-ol 
• 146564-12-7 1-Benzenesulfonyl-7-(4-chloro-phenylsulfanyl)-4-trimethylsilanyloxy-4,5,6,7-tetrahydro-1H-indole-4-carbonitrile 
• 146564-14-9 methyl <1-(phenylsulfonyl)-1H-indol-4-ylthio>acetate 
• 95969-13-4 1-Benzenesulfonyl-4-hydroxy-1H-indole 
• 79315-62-1 4-(benzyloxy)-1-(phenylsulfonyl)-1H-indole 
• 157396-16-2 1-Benzenesulfonyl-7-(4-chloro-benzenesulfinyl)-1,5,6,7-tetrahydro-indol-4-one 

Relevant articles and documents

New, concise route to indoles bearing oxygen or sulfur substituent at the 4-position. Synthesis of (±)- and (S)-(-)-pindolol and (±)-chuangxinmycin

A new method for the synthesis of 4-alkoxy- and 4-[alkyl (or aryl)thio]indoles has been developed by using the indolone 3 as a common intermediate. The indolone 3 was prepared from N-(phenylsulfonyl)pyrrole (7) and the α-chlorosulfide 8 in four steps. Heating of a mixture of 3 and an appropriate alcohol in the presence of p-toluenesulfonic acid and cupric chloride afforded the 4-alkoxyindoles 11a-d. The method was applied to the synthesis of (±)-pindolol (19) and (S)-(-)-pindolol (20). Thiols also reacted with 3 in the presence of boron trifluoride to give 4-[aryl (or alkyl)thio]indoles 12, 21a, b, and 22a-d. The (indol-4-ylthio)acetate 22c was employed as a key intermediate for a concise total synthesis of (±)- chuangxinmycin (27).