1574222-40-4

Basic information

• Product Name: N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-2-(2-iodophenoxy)acetamide
• CAS NO: 1574222-40-4
• Molecular Weight: 421.237
• Mol File: 1574222-40-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-2-(2-iodophenoxy)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-2-(2-iodophenoxy)acetamide(1574222-40-4)
• EPA Substance Registry System: N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-2-(2-iodophenoxy)acetamide(1574222-40-4)

Safety Data

• Hazardous Substances Data: 1574222-40-4(Hazardous Substances Data)

Upstream product

• 1878-92-8 2-(2-iodophenoxy)acetic acid 
• 4499-07-4 2-(1H-benzo[d]imidazol-2-yl)ethanamine dihydrochloride 
• 20143-42-4 <2-Iod-phenoxy>-acetylchlorid 

Relevant articles and documents

Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents

The development of cruzain inhibitors has been driven by the urgent need to develop novel and more effective drugs for the treatment of Chagas' disease. Herein, we report the lead optimization of a class of noncovalent cruzain inhibitors, starting from an inhibitor previously cocrystallized with the enzyme (Ki = 0.8 μM). With the goal of achieving a better understanding of the structure-activity relationships, we have synthesized and evaluated a series of over 40 analogues, leading to the development of a very promising competitive inhibitor (8r, IC50 = 200 nM, Ki = 82 nM). Investigation of the in vitro trypanocidal activity and preliminary cytotoxicity revealed the potential of the most potent cruzain inhibitors in guiding further medicinal chemistry efforts to develop drug candidates for Chagas' disease.