1878-92-8

Basic information

• Product Name: 2-Iodophenoxyacetic acid
• Synonyms: (2-Iodophenoxy)acetic acid;(o-Iodophenoxy)acetic acid;2-Iodophenoxyacetic acid;Acetic acid, 2-(2-iodophenoxy)-
• CAS NO: 1878-92-8
• Molecular Formula: C₈H₇IO₃
• Molecular Weight: 278.04
• Mol File: 1878-92-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 361.1±22.0 °C(Predicted)
• Appearance: /
• Density: 1.896±0.06 g/cm3(Predicted)
• PKA: pK1:3.17 (25°C)
• CAS DataBase Reference: 2-Iodophenoxyacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodophenoxyacetic acid(1878-92-8)
• EPA Substance Registry System: 2-Iodophenoxyacetic acid(1878-92-8)

Safety Data

• Hazardous Substances Data: 1878-92-8(Hazardous Substances Data)

Upstream product

• 533-58-4 2-Iodophenol 
• 105-36-2 ethyl bromoacetate 
• 79-08-3 bromoacetic acid 
• 1229805-95-1 tert-butyl 2-(2-iodophenoxy)acetate 
• 79-11-8 chloroacetic acid 
• 90794-32-4 2-([(ethoxycarbonyl)methylene]oxy)-1-iodobenzene 
• 186395-08-4 methyl 2-(2-iodophenoxy)acetate 

Downstream Products

• 278598-73-5 (2S)-3-(4-{[(4-{[2-(4-chlorophenyl)acetyl]amino}-1-piperidinyl)carbonyl]oxy}phenyl)-2-[((2S)-2-{[2-(2-iodophenoxy)acetyl]amino}-4-methyl pentanoyl)amino]propanoic acid 
• 54799-66-5 3,4-dihydro-3-oxo-4-phenyl-2H-1,4-benzoxazine 
• 20143-42-4 <2-Iod-phenoxy>-acetylchlorid 
• 1569294-10-5 N-(2-(N,N-diethylamino)ethyl)-6-(2-(2-iodophenoxy)acetamido)quinoxaline-2-carboxamide 
• 1574222-40-4 N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-2-(2-iodophenoxy)acetamide 
• 13359-10-9 <2-Iod-phenoxy>-acethydroxamsaeure 
• 533-58-4 2-Iodophenol 
• 186395-08-4 methyl 2-(2-iodophenoxy)acetate 
• 90794-32-4 2-([(ethoxycarbonyl)methylene]oxy)-1-iodobenzene 

Relevant articles and documents

Synthesis of N-Glycosyl-2-oxindoles by Pd-Catalyzed N-Arylation of 1-Amidosugars

An efficient intramolecular Pd-catalyzed N-arylation of o-iodo-amidosugars for the synthesis of N-glycosylated oxindoles has been reported. The coupling reaction takes place in toluene and involves Pd(OAc)2/RuPhos catalytic systems in the presence of K2CO3. This versatile approach was extended successfully to the synthesis of other N-glycosylated heterocycles.

Synthesis and biological evaluation of new quinoxaline derivatives of ICF01012 as melanoma-targeting probes

The aim of this study was the synthesis and pharmacokinetic selection of a best melanin-targeting ligand for addressing anticancer agents to pigmented melanoma. Seven quinoxaline carboxamide derivatives were synthesized and radiolabeled with iodine-125. Biodistribution studies of compounds [ 125I]1a-g performed in melanoma-bearing mice tumor showed significant tumor uptake (range 2.43-5.68%ID/g) within 1 h after i.v. injection. Fast clearance of the radioactivity from the nontarget organs mainly via the urinary system gave high tumor-to-blood and tumor-to-muscle ratios. Given its favorable clearance and high tumor-melanoma uptake at 72 h, amide 1d was the most promising melanoma-targeting ligand in this series. Compound 1d will be used as building block for the design of new melanoma-selective drug delivery systems.

COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES

There are provided according to the invention, novel compounds of formula (I)wherein R, R, R, R, Rand Rare as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.