157427-91-3Relevant academic research and scientific papers
Catalytic Dealkylative Synthesis of Cyclic Carbamates and Ureas via Hydrogen Atom Transfer and Radical-Polar Crossover
Nagai, Takuya,Mimata, Nao,Terada, Yoshihiro,Sebe, Chikayoshi,Shigehisa, Hiroki
, p. 5522 - 5527 (2020)
Guided by the transition-metal hydrogen atom transfer and radical-polar crossover concepts, we developed a functional-group-tolerant and scalable method for the synthesis of cyclic carbamates and ureas, which are found in the structures of bioactive compo
Discovery of novel quinolinone adenosine A2B antagonists
McGuinness, Brian F.,Ho, Koc-Kan,Stauffer, Tara M.,Rokosz, Laura L.,Mannava, Neelima,Kultgen, Steven G.,Saionz, Kurt,Klon, Anthony,Chen, Weiqing,Desai, Hema,Rogers, W. Lynn,Webb, Maria,Yin, Juxing,Jiang, Yan,Li, Tailong,Yan, Hao,Jing, Konghua,Zhang, Shengting,Majumdar, Kanak Kanti,Srivastava, Vikash,Saha, Samiran
scheme or table, p. 7414 - 7420 (2011/02/23)
A novel series of quinolinone-based adenosine A2B receptor antagonists was identified via high throughput screening of an encoded combinatorial compound collection. Synthesis and assay of a series of analogs highlighted essential structural features of the initial hit. Optimization resulted in an A2B antagonist (2i) which exhibited potent activity in a cAMP accumulation assay (5.1 nM) and an IL-8 release assay (0.4 nM).
Synthetic Studies on Dynemicin A. New Quinoline Synthesis for C, D and E Rings
Nishikawa, Toshio,Isobe, Minoru
, p. 5621 - 5632 (2007/10/02)
The important intermediates for the syntheses of dynemicin A model compounds were prepared by coupling between aryltin compounds and α-bromoenone derivatives in the presence of palladium catalyst.The products were transformed under acidic conditions to su
