111359-74-1Relevant articles and documents
Design and synthesis of acetaminophen probe APAP-P1 for identification of the toxicity targets thioredoxin reductase-1 in HepaRG cells
Wang, Shan,Tian, Yu,Lu, Shan,Wang, Ruiying,Shang, Hai,Zhang, Xuelian,Zhang, Chenyang,Sun, Guibo,Xu, Xudong,Sun, Xiaobo
, p. 15224 - 15228 (2019)
Drug-induced liver injury is one of the main causes of drug non-approval and drug withdrawal by the Food and Drug Administration (FDA). Acetaminophen (APAP) is a widely used non-steroidal anti-inflammatory drug for treating fever and headache. APAP is con
A GENERAL PROCEDURE FOR THE CATALYTIC HYDROGENOLYSIS OF N-BENZYLAMINES UNDER EXTREMELY MILD CONDITIONS.
Yoshida, Kiyoshi,Nakajima, Shigekazu,Wakamatsu, Takeshi,Ban, Yoshio,Shibasaki, Masakatsu
, p. 1167 - 1168 (1988)
A general procedure for debenzylation of N-benzylamines, which contain acid sensitive functional groups, by the catalytic hydrogenolysis using 20percent Pd(OH)2-C is reported.
Selective primary aniline synthesis through supported Pd-catalyzed acceptorless dehydrogenative aromatization by utilizing hydrazine
Lin, Wei-Chen,Yatabe, Takafumi,Yamaguchi, Kazuya
supporting information, p. 6530 - 6533 (2021/07/07)
By utilizing hydrazine (N2H4) as the nitrogen source in the presence of a hydroxyapatite-supported Pd nanoparticle catalyst (Pd/HAP), various primary anilines can be selectively synthesized from cyclohexanonesviaacceptorless dehydrogenative aromatization. The strong nucleophilicity of N2H4and the stability of the hydrazone intermediates can effectively suppress the formation of the undesired secondary aniline byproducts.
METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE
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Paragraph 00616; 00618; 00635; 00636, (2021/08/13)
The present disclosure relates to compounds and methods for modulating the expression of dmpk, and treating diseases and conditions in which dmpk plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence CAG or CTG; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence CAG or CTG; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.