157430-04-1

Basic information

• Product Name: 2-(2-bromo-4,5-dimethoxyphenyl)-[1,3]dithiane
• Synonyms: 2-(2-bromo-4,5-dimethoxyphenyl)-[1,3]dithiane
• CAS NO: 157430-04-1
• Molecular Weight: 335.286
• Mol File: 157430-04-1.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-bromo-4,5-dimethoxyphenyl)-[1,3]dithiane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromo-4,5-dimethoxyphenyl)-[1,3]dithiane(157430-04-1)
• EPA Substance Registry System: 2-(2-bromo-4,5-dimethoxyphenyl)-[1,3]dithiane(157430-04-1)

Safety Data

• Hazardous Substances Data: 157430-04-1(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 173070-70-7 (4-Benzyloxy-3,5-dimethoxy-phenyl)-(2-[1,3]dithian-2-yl-4,5-dimethoxy-phenyl)-methanol 
• 173070-68-3 (2-[1,3]Dithian-2-yl-4,5-dimethoxy-phenyl)-(3,4,5-trimethoxy-phenyl)-methanol 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 17951-19-8 justicidin B 
• 157430-06-3 (2-[1,3]Dithian-2-yl-4,5-dimethoxy-phenyl)-(3,4,5-trimethoxy-phenyl)-methanone 
• 157430-07-4 (4-Benzyloxy-3,5-dimethoxy-phenyl)-(2-[1,3]dithian-2-yl-4,5-dimethoxy-phenyl)-methanone 

Relevant articles and documents

Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa

Justicia gendarussa, a medicinal plant collected in Vietnam, was identified as a potent anti-HIV-1 active lead from the evaluation of over 4500 plant extracts. Bioassay-guided separation of the extracts of the stems and roots of this plant led to the isolation of an anti-HIV arylnaphthalene lignan (ANL) glycoside, patentiflorin A (1). Evaluation of the compound against both the M-and T-Tropic HIV-1 isolates showed it to possess a significantly higher inhibition effect than the clinically used anti-HIV drug AZT. Patentiflorin A and two congeners were synthesized, de novo, as an efficient strategy for resupply as well as for further structural modification of the anti-HIV ANL glycosides in the search for drug leads. Subsequently, it was determined that the presence of a quinovopyranosyloxy group in the structure is likely essential to retain the high degree of anti-HIV activity of this type of compounds. Patentiflorin A was further investigated against the HIV-1 gene expression of the R/U5 and U5/gag transcripts, and the data showed that the compound acts as a potential inhibitor of HIV-1 reverse transcription. Importantly, the compound displayed potent inhibitory activity against drug-resistant HIV-1 isolates of both the nucleotide analogue (AZT) and non-nucleotide analogue (nevaripine). Thus, the ANL glycosides have the potential to be developed as novel anti-HIV drugs.

ARYL NAPHTHALIDE LIGNANS AS ANTI-HIV AGENTS

Provided herein are glycosidic aryl naphthalide lignans compounds, such as justiprocumin A isolated from the plant Justicia gendarussa Burm.f. (Acanthaceae), which are effective in the treatment of AIDS and HIV infections.

A Rapid Entry into Podophyllotoxin Congeners: Synthesis of Justicidin B

A facile synthesis of justicidin B is described, as well as related podophyllum lignans by employing Michael Initiated Ring Clousere Strategy followed by desulfurization mediated by nickel-containing complex reducing agent. - Key words: podophyllotoxin, podophyllum lignans, justicidin B., Michael initiated Ring Closure, desulfurization, nickel-containing complex reducing agent.