157435-84-2

Upstream product

• 157435-83-1 (R)-2-Azetidinepropanoic acid 4-oxo-1-(phenylmethoxy)-(1,1-dimethylethyl) ester 
• 157435-79-5 (S)-Hexanedioic acid 3-hydroxy-1-methyl-6-(1,1-dimethylethyl)ester 
• 157435-81-9 (S)-Hexanoic acid 4-hydroxy-6-oxo-6-<(phenylmethoxy)amino>-(1,1-dimethylethyl) ester 
• 93740-92-2 Hexanedioic acid 3-oxo-1-methyl-6-(1,1-dimethylethyl)ester 
• 15026-17-2 succinic acid mono-tert-butyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 1026968-65-9 3-((R)-1-Hydroxy-4-oxo-azetidin-2-yl)-propionic acid tert-butyl ester 
• 157435-82-0 (R)-2-Azetidinepropanoic acid 1-(1-oxoethoxy)-4-oxo-(1,1-dimethylethyl) ester 
• 157435-80-8 (S)-Hexanoic acid 4-hydroxy-6-oxo-6-<(1-oxoethoxy)amino>-(1,1-dimethylethyl) ester 

Downstream Products

• 157435-88-6 (2R,3R)-2-Azetidinepropanoic acid 1-<2-(phenylmethoxy)-2-oxoethyl>-4-oxo-3-azidophenyl ester 
• 157435-86-4 (2R,3R)-2-Azetidinepropanoic acid 1-<2-(phenylmethoxy)-2-oxoethyl>-4-oxo-3-azido-(1,1-dimethylethyl) ester 
• 157435-87-5 (2R,3R)-2-Azetidinepropanoic acid 1-<2-(phenylmethoxy)-2-oxoethyl>-4-oxo-3-azide 

Relevant academic research and scientific papers

Catalytic, Asymmetric Synthesis of the Carbacephem Framework

A catalytic, asymmetric synthesis of the carbacephem β-lactam framework is reported.The initial asymmetric center was established by catalytic hydrogenation of β-keto ester 12 with (S)-Ru-BINAP.The β-lactam ring was prepared using the hydroxamate approach (14 -> 15).The nitrogen substituent at C7 was introduced by the nucleophile transfer reaction (15 -> 17), and the six-membered ring of the carbacephem was prepared by a directed Dieckmann condensation (24 -> 25).