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Relevant academic research and scientific papers

Unusual sesquiterpene glucosides from Amaranthus retroflexus

Implementing the phytochemical study of the weed Amaranthus retroflexus, four new sesquiterpene glucosides were isolated from the methanolic extract of the plant. The structures of these metabolites are determined on the basis of the mass spectrometry, and 1D and 2D NMR spectroscopies (DQ-COSY, TOCSY, HSQC, HSQC-TOCSY, HMBC, and NOESY). Two compounds are characterized by a new aglycone and differed from the site of glucosylation. The other two compounds are dimeric diastereoisomers. All the glucoside sesquiterpenes were tested on the wild species Taraxacum officinale to evaluate the role of this weed in the habitat and on the seed of A. retroflexus to verify the potential autotoxic effect of the plant.

Use of diamines containing the α-phenylethyl group as chiral ligands in the asymmetric hydrosilylation of prochiral ketones

Chiral diamines 1-7 were used in the enantioselective hydrosilylation of prochiral aromatic and aliphatic ketones. Some of these ligands combine chiral backbones and chiral N,N′-α-phenylethyl substituents that give rise to synergistic effects between these two groups and lead to catalysts that exhibit high enantioselectivity.

Synthesis of new chiral derivatives of N,N′-dimethylpropyleneurea (DMPU) and examination of their influence on the regio- and enantioselectivity of addition of 2-(1,3-dithianyl)lithium to cyclohex-2-en-1-one

The preparation of three new chiral derivatives of DMPU (N,N′-dimethylpropyleneurea) is described (Schemes 2-4); one type of derivative carries 1-phenylethyl or 1-cyclohexylethyl groups at the N-atoms of the tetrahydropyrimidin-2(1H)-one ring (2 and 4), a

New bidentate chiral phosphoramidites in copper-catalyzed asymmetric 1,4-addition of diethylzinc to cyclic α,β-enones: Enantioselective tandem 1,4-addition-aldol reactions with 2-cyclopentenone

New bidentate phosphoramidites were prepared starting from α,α,α′,α′-tetraphenyl-2,2-dimethyl-1, 3-dioxolane-4,5-dimethanol (TADDOL) or 1,1′-bi-2-naphthol (BINOL) and either 1,2-ethylene- or 1,3-propylenediamine N,N′-disubstituted with achiral or chiral groups. The use of these ligands in the copper-catalyzed enantioselective conjugate addition of diethylzinc to 2-cyclohexenone and 2-cyclopentenone afforded products with e.e.s of up to 89 and 83%, respectively.

α-Phenylethylamine based chiral phospholidines; new agents for the determination of the enantiomeric excess of chiral alcohols, amines and thiols by means of 31P NMR

The synthesis and application of two new trivalent phosphorus derivatizing agents, based upon (S)-α-phenylethylamine, for the enantiomeric excess determination of alcohols, amines and thiols using 31P NMR, is presented.