1575-46-8

Basic information

• Product Name: 3,4-Dimethyl-2,5-dihydrofuran-2-one
• Synonyms: 3,4-Dimethyl-2,5-dihydrofuran-2-one;3,4-Dimethylfuran-2(5H)-one;3,4-DiMethyl-2(5H)-furanone
• CAS NO: 1575-46-8
• Molecular Formula: C₆H₈O₂
• Molecular Weight: 112.1265
• Mol File: 1575-46-8.mol
• Article Data: 15

Chemical Properties

• Melting Point: 33-34 °C
• Boiling Point: 224.7°Cat760mmHg
• Flash Point: 84.5°C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 0.0897mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3,4-Dimethyl-2,5-dihydrofuran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dimethyl-2,5-dihydrofuran-2-one(1575-46-8)
• EPA Substance Registry System: 3,4-Dimethyl-2,5-dihydrofuran-2-one(1575-46-8)

Safety Data

• Hazardous Substances Data: 1575-46-8(Hazardous Substances Data)

Usage

Uses

3,4-Dimethyl-2(5H)-furanone is an intermediate in the synthesis of 3,4-Dimethyl-5-pentyl-2-furannonanoic Acid (D477715), an F3 furan fatty acid that exhibits radical-scavenging ability and anti-inflammatory properties.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 31, p. 893, 1988 DOI: 10.1021/jm00400a001

InChI:InChI=1/C6H8O2/c1-4-3-8-6(7)5(4)2/h3H2,1-2H3

Upstream product

• 14387-99-6 ethyl 2,3-dimethyl-3-butenoate 
• 201230-82-2 carbon monoxide 
• 4626-58-8 benzyl(but-2-yn-1-yl)amine 
• 22742-89-8 2-methyl-2,3-butadiene-1-ol 
• 766-39-2 2,3-Dimethylmaleic anhydride 
• 592-20-1 Acetol acetate 
• 535-11-5 Ethyl 2-bromopropionate 
• 34757-17-0 ethyl 2,2-dibromopropanoate 
• 118171-02-1 1-(tert-butyldiphenylsilyloxy)-2-propanone 
• 877869-60-8 (Z)-methyl 4-(tert-butyldiphenylsiloxy)-2,3-dimethyl-2-butenoate 
• 1004788-37-7 3,4-dimethyl-5-oxotetrahydrofuran-3-yl acetate 
• 80248-53-9 Formic acid 4,4-dimethoxy-2,3-dimethyl-oxetan-2-ylmethyl ester 
• 80248-58-4 (4,4-Dimethoxy-2,3-dimethyl-oxetan-2-yl)-methanol 
• 18141-46-3 diethyl 2-[1-(trimethylsilyl)ethyl]malonate 

Downstream Products

• 20843-07-6 3,4-dimethylfuran 

Relevant articles and documents

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Carbonylation of Aldehydes in Strong Acid. A General Synthesis of 3,4-Dialkyl-2(5H)-furanones

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Expeditious microwave-assisted synthesis of 5-alkoxyoxazoles from α-triflyloxy esters and nitriles

A rapid and general access to diversely substituted 5-alkoxyoxazoles 2 (i.e., R1, R2 = alkyl, phenyl) from easily accessible α-triflyloxy/hydroxy esters 1 and nitriles with good yields (41-76%) is reported. The versatility of the cyc

Synthesis of hetero atom modified pyrromethenones

A series of six heteroaromatic compounds, ethyl-/methyl-and dimethylfuranones, thiophenones, and cyclopentenones, was synthesized and condensed with a methyl methylpropionate substituted pyrrole, yielding the "right" half of open-chain tetrapyrroles. These compounds serve as light-inducible chromophores in the plant photoreceptor phytochrome. Three-dimensional structure analysis of the 10-oxapyrromethen-1-one 25 revealed a planar conformation, similar to the dipyrromethenone parent compound, stabilized by a hydrogen bond formed between the pyrrole proton and the furanone oxygen atom. All six pyrrole-substituted heteroaromatic derivatives 25-30 show absorbances in the visible spectrum with high molar extinction coefficients. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.