15753-61-4

Upstream product

• 106-49-0 p-toluidine 
• 15397-33-8 3-Oxo-3-phenylpropanal 
• 7732-18-5 water 
• 98-86-2 acetophenone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 72374-63-1 N-(4-Methylphenyl)-1-phenylpropanimine 
• 72374-72-2 N-1-(2,2-Dichlor-1-phenyl-propyliden)-p-methyl-anilin 

Downstream Products

• 98879-30-2 Bis-<2-p-toluidino-1-benzoyl-vinyl>-sulfid 
• 1401856-08-3 ((4S,6R)-6-hydroxy-4-phenyl-1-p-tolyl-1,4,5,6-tetrahydropyridin-3-yl)(phenyl)methanone 

Relevant academic research and scientific papers

Copper-catalyzed carbene insertion and ester migration for the synthesis of polysubstituted pyrroles

Copper-catalyzed carbene insertion/ester migration/cyclization of enaminones and α-diazo compounds occurred efficiently to afford 2-ester polysubstituted pyrroles under mild conditions in moderate-to-good yields. Substituent functionality was well tolerated and13C-labelled experiments demonstrated 1,2-ester migration during the reaction.

Mannich Reaction with Enaminones: Convenient Synthesis of Functionalized Tetrahydro-pyrimidines, Dihydro-1,3-oxazines, and Dihydro-1,2,4-triazepines

A series of tetrahydropyrimidines and bis-(tetrahydropyrimidines) was synthesized by Mannich reaction of sec-emaminones with formaldehyde and the appropriate amine or diamine. Whereas the reaction with formaldehyde gave the dihydro-1,3-oxazine. Tetrahydro

Iodine-mediated synthesis of sulfur-bridged enaminones and chromones: Via double C(sp2)-H thiolation

The reactions of various enaminones with elemental sulfur giving rise to both sulfur-bridged enaminones and chromones have been realized via iodine promotion. All products were furnished by means of double C(sp2)-H bond thiolation without using

Base-Promoted Synthesis of N-Substituted 1,2,3-Triazoles via Enaminone-Azide Cycloaddition Involving Regitz Diazo Transfer

The domino reactions between NH-based secondary enaminones and tosyl azide have been developed for the synthesis of various N-substituted 1,2,3-triazoles by employing t-BuONa as the base promoter. Through a key Regitz diazo-transfer process with tosyl azi

Novel tetrahydropyrimidine-adamantane hybrids as anti-inflammatory agents: Synthesis, structure and biological evaluation

A series of novel (3-((3s,5s,7s)-adamantan-1-yl)-1-alkyl/aralkyl/aryl-1,2,3,4-tetrahydroyrimidin-5-yl)(aryl)methanones (5a-j) has been synthesized by the reaction of 1-aryl-3-(alkyl/aralkyl/aryl)aminoprop-2-en-1-ones 3a-j, 1-adamantanamine 4 and formaldehyde under thermal conditions. The structures of the products (5a-j) have been established with the help of spectral and analytical data. The stereochemistry of the products was established by X-ray crystallographic studies of a representative product (3-((3s,5s,7s)-adamantan-1-yl)-1-methyl-1,2,3,4-tetrahydropyrimidin-5-yl)(4-chlorophenyl) methanone (5g) of the series. The target adamantane-tetrahydropyrimidine hybrids 5a-j were evaluated for their anti-inflammatory activities as a result of which compounds 5e (R=C6H5CH2, Ar=C6H5), 5i (R=CH3, Ar=4-CH3C6H4), 5j (R=C6H5CH2, Ar=4-CH3C6H4) and 5g (R=CH3, Ar=4-ClC6H4) were found to exhibit excellent and promising anti-inflammatory activities.

Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2- ols

The asymmetric synthesis of tetrahydropyridin-2-ols from enals and enaminones is described. The organocatalytic domino reaction involves a Michael addition-hemiaminalization sequence using the Jorgensen-Hayashi catalyst. Dehydration or oxidation leads to the corresponding 1,4-dihydro-pyridines or 3,4-dihydropyridin-2-ones in a one-pot fashion. The Royal Society of Chemistry 2012.