157547-57-4Relevant academic research and scientific papers
Benzoate derivatives of taxol
-
, (2008/06/13)
This invention relates to a compound of formula I STR1 or a pharmaceutically acceptable salt thereof, in which R2 is a radical of the formula STR2 in which Ra and Rb are independently hydrogen or C1-6 alkyl, said C1-6 alkyl being optionally substituted with hydroxy, phosphono, phosphonooxy, carboxy or di(C1-6 alkyl) amino; or NRa Rb together represents a radical of the formula STR3 in which y is one to three, and Ra is as defined above; Rp and Rr are independently same or different C1-6 alkyl; R1 is hydrogen or a radical Z of the formula STR4 in which Q is --(CH2)f --, optionally substituted with one to six same or different C1-6 alkyl or C3-6 cycloalkyl, or a carbon atom of said --(CH2)f -- radical may also be a part of C3-6 cycloalkylidene; R3 and R4 are independently hydrogen or C1-6 alkyl, or R3 and R4 taken together with the carbon atom to which they are attached form C3-6 cycloalkylidene; R5 is --OC(=O)R, --OP=O(OH)2 or --CH2 OP=O(OH)2, in which R is C1-6 alkyl; R6, R7, R8 and R9 are independently halogen, C1-6 alkyl, C1-6 alkoxy or hydrogen, but when R5 is --OC(=O)R, one of R6, R7, R8 or R9 is --OP=O(OH)2 ; f is 2 to 6; n is O, and m is 1 or 0 when R5 is --CH2 OP=O(OH)2 ; and n is 1 or 0, and m is 1 when R5 is --OC(=O)R or --OP=O(OH)2. Also provided by this invention are pharmaceutical formulations and a method for treating mammalian tumors with a compound of formula I.
