1575480-87-3Relevant academic research and scientific papers
Synthesis and characterization of novel benzo[d][1,3]dioxole gathered pyrazole derivatives and their antimicrobial evaluation
Umesha, Basavaiah,Basavaraju, Yeriyur Basavaiah
, p. 3744 - 3751 (2014/08/05)
Benzo[d][1,3]dioxole gathered pyrazole derivatives (4a-i) were synthesized by the reaction of chalcones with phenyl hydrazine in presence of absolute alcohol as a solvent. Chalcones were prepared by the Claisen-Schmidt reaction between 1-(benzo[d][1,3]dioxol-5-yl)ethanone (2) and substituted aromatic aldehydes. The synthesized compounds were characterized by spectral and elemental analysis data. Furthermore, Benzo[ d][1,3]dioxole gathered pyrazole derivatives (4a-i) were evaluated for their in vitro antimicrobial activity. Among the newly synthesized compounds 4a, 4c, 4 g and 4 h showed the excellent antifungal activity and as well as 4a and 4d showed the excellent antibacterial activity when compared to other compounds. Springer Science+Business Media 2014.
